Shao Ya, Wang Yu, Jiang Xuelian, Shao Meiling, Liu Bin, Li Longti, Zhong Huiqin
Health Management Center, Wudangshan Branch, TaiHe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Nursing Department, TaiHe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Front Endocrinol (Lausanne). 2025 May 27;16:1562837. doi: 10.3389/fendo.2025.1562837. eCollection 2025.
The relationship between the Muscle Quality Index (MQI) and hyperuricemia remains incompletely defined, and additional studies are necessary to elucidate the mediating role of adipose tissue in this association.
This study utilized data from the 2011-2014 National Health and Nutrition Examination Survey (NHANES) and included 5,198 adults. MQI was calculated as the ratio of maximum handgrip strength to appendicular skeletal muscle mass (ASM), and adipose tissue parameters included body fat percentage (BF%) and visceral fat mass (VFM). To examine the link between MQI and hyperuricemia, multiple logistic regression models were employed, and generalized additive models were utilized to assess potential non-linear patterns. Mediation analysis was performed to assess the mediating effect of adipose tissue, and sensitivity analyses, which involved altering the thresholds for hyperuricemia and excluding individuals with major chronic conditions, were carried out to verify the consistency of the results.
When treated as a continuous variable, MQI demonstrated a strong inverse association with hyperuricemia. Each one-unit increment in MQI corresponded to a 50% decrease in the odds of hyperuricemia (OR: 0.50, 95% CI: 0.43-0.57). Quartile-based analysis revealed that individuals in the highest MQI quartile had a 68% lower odds of developing hyperuricemia compared to those in the lowest quartile (OR: 0.32, 95% CI: 0.25-0.41). Subgroup analyses confirmed this negative correlation across various strata, and sensitivity analyses showed consistent results. Mediation analysis indicated that BF% and VFM explained 49.32% and 53.62% of the association between MQI and hyperuricemia, respectively.
This study reveals a significant negative correlation between MQI and hyperuricemia, mediated by adipose tissue. These findings suggest that improving muscle quality and managing adipose tissue could offer new strategies for mitigating hyperuricemia and promoting better public health outcomes.
肌肉质量指数（MQI）与高尿酸血症之间的关系尚未完全明确，需要更多研究来阐明脂肪组织在这种关联中的中介作用。
本研究使用了2011 - 2014年美国国家健康与营养检查调查（NHANES）的数据，纳入了5198名成年人。MQI计算为最大握力与四肢骨骼肌质量（ASM）的比值，脂肪组织参数包括体脂百分比（BF%）和内脏脂肪量（VFM）。为了研究MQI与高尿酸血症之间的联系，采用了多个逻辑回归模型，并使用广义相加模型来评估潜在的非线性模式。进行中介分析以评估脂肪组织的中介作用，并进行敏感性分析，包括改变高尿酸血症的阈值和排除患有主要慢性病的个体，以验证结果的一致性。
当将MQI视为连续变量时，它与高尿酸血症呈现出强烈的负相关。MQI每增加一个单位，高尿酸血症的患病几率就降低50%（OR：0.50，95%CI：0.43 - 0.57）。基于四分位数的分析显示，与最低四分位数的个体相比，最高MQI四分位数的个体患高尿酸血症的几率低68%（OR：0.32，95%CI：0.25 - 0.41）。亚组分析证实了各层之间的这种负相关，敏感性分析显示结果一致。中介分析表明，BF%和VFM分别解释了MQI与高尿酸血症之间关联的49.32%和53.62%。
本研究揭示了MQI与高尿酸血症之间存在显著的负相关，且由脂肪组织介导。这些发现表明，改善肌肉质量和管理脂肪组织可能为减轻高尿酸血症和促进更好的公共卫生结果提供新的策略。
