Pitt H A, Mann L L, Berquist W E, Ament M E, Fonkalsrud E W, DenBesten L
Arch Surg. 1985 May;120(5):614-8. doi: 10.1001/archsurg.1985.01390290090015.
A variety of remedies have been suggested for patients with chronic intestinal pseudo-obstruction. However, none of these treatments have been particularly effective, and many of these patients have died of malnutrition. Therefore, in an effort to maintain nutrition and avoid repetitive nasogastric intubation, 22 patients (12 adults and ten children) with chronic intestinal pseudo-obstruction were managed with long-term total parenteral nutrition (TPN), and 20 also received a "venting" enterostomy. Only two patients had to undergo revision of their gastrostomies. Prior to referral, these 22 patients required 56 admissions for obstruction (1.2 admissions per patient-year). Since the initiation of TPN and placement of a venting enterostomy, these 22 patients required only 17 hospitalizations for obstruction in a total of 80 patient years (0.2 admissions per patient-year). We conclude that patients with chronic intestinal pseudo-obstruction who receive TPN at home and have a venting enterostomy can be safely managed for prolonged periods and require fewer hospitalizations for obstruction.
对于慢性肠假性梗阻患者，已经提出了多种治疗方法。然而，这些治疗方法均未取得特别显著的效果，许多此类患者死于营养不良。因此，为了维持营养并避免反复进行鼻胃管插管，对22例慢性肠假性梗阻患者（12例成人和10例儿童）采用长期全胃肠外营养（TPN）进行治疗，其中20例还接受了“排气”肠造口术。只有2例患者需要对胃造口进行修复。在转诊之前，这22例患者因梗阻需要住院56次（每位患者每年1.2次住院）。自开始进行TPN和实施排气肠造口术以来，在总共80个患者年中，这22例患者因梗阻仅需住院17次（每位患者每年0.2次住院）。我们得出结论，在家中接受TPN并进行排气肠造口术的慢性肠假性梗阻患者可以得到长期安全的管理，并且因梗阻需要住院的次数较少。
