肠道守护者：丁酸调节的FUT2可预防实验性坏死性小肠结肠炎。 - Suppr

Guardian of the gut: butyrate-regulated FUT2 protects against experimental NEC.

作者信息

Venkatraman Aparna, Morelli John J, Sampath Venkatesh

机构信息

Division of Neonatology, Department of Pediatrics, Children's Mercy Kansas City, Neonatal Diseases Research Program, Children's Mercy Research Institute, Children's Mercy Kansas City, Kansas City, MO, 64108, USA.

出版信息

Pediatr Res. 2025 Jan;97(1):25-26. doi: 10.1038/s41390-024-03522-8. Epub 2024 Aug 29.

DOI:10.1038/s41390-024-03522-8

PMID:39210051

Abstract

摘要

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Alterations of the gut microbiota and short chain fatty acids in necrotizing enterocolitis and food protein-induced allergic protocolitis infants: A prospective cohort study.

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Sodium Butyrate Alleviates Intestinal Inflammation in Mice with Necrotizing Enterocolitis.

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Cell Mol Gastroenterol Hepatol. 2022;13(2):425-440. doi: 10.1016/j.jcmgh.2021.09.009. Epub 2021 Sep 23.

Exogenous l-fucose protects the intestinal mucosal barrier depending on upregulation of FUT2-mediated fucosylation of intestinal epithelial cells.

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Mol Immunol. 2021 Mar;131:23-32. doi: 10.1016/j.molimm.2020.12.036. Epub 2021 Jan 16.

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Guardian of the gut: butyrate-regulated FUT2 protects against experimental NEC.

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