State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China.
Department of Animal Science, Oklahoma State University, Stillwater, OK; Departments of Internal Medicine and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX.
Adv Nutr. 2018 Jan 1;9(1):21-29. doi: 10.1093/advances/nmx009.
Butyrate, a four-carbon short-chain fatty acid, is produced through microbial fermentation of dietary fibers in the lower intestinal tract. Endogenous butyrate production, delivery, and absorption by colonocytes have been well documented. Butyrate exerts its functions by acting as a histone deacetylase (HDAC) inhibitor or signaling through several G protein-coupled receptors (GPCRs). Recently, butyrate has received particular attention for its beneficial effects on intestinal homeostasis and energy metabolism. With anti-inflammatory properties, butyrate enhances intestinal barrier function and mucosal immunity. However, the role of butyrate in obesity remains controversial. Growing evidence has highlighted the impact of butyrate on the gut-brain axis. In this review, we summarize the present knowledge on the properties of butyrate, especially its potential effects and mechanisms involved in intestinal health and obesity.
丁酸盐是一种四碳短链脂肪酸，通过肠道下段膳食纤维的微生物发酵产生。结肠细胞的内源性丁酸盐产生、输送和吸收已有充分的文献记载。丁酸盐通过作为组蛋白去乙酰化酶（HDAC）抑制剂或通过几种 G 蛋白偶联受体（GPCR）发挥作用。最近，丁酸盐因其对肠道内稳态和能量代谢的有益作用而受到特别关注。丁酸盐具有抗炎特性，可增强肠道屏障功能和黏膜免疫。然而，丁酸盐在肥胖中的作用仍存在争议。越来越多的证据强调了丁酸盐对肠-脑轴的影响。在这篇综述中，我们总结了丁酸盐特性的现有知识，特别是其在肠道健康和肥胖中涉及的潜在作用和机制。
