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印度老年人慢性病负担与家族病史状况

The Burden of Chronic Diseases with the Status of Family Medical History Among Older Adults in India.

作者信息

Bramhankar Mahadev, Pandey Mohit, Tyagi Rishabh

机构信息

Department of Biostatistics and Demography, International Institute for Population Sciences, Mumbai, India.

Max Planck Institute of Demographic Research, Rostock, Germany.

出版信息

J Prev (2022). 2025 Feb;46(1):83-101. doi: 10.1007/s10935-024-00802-1. Epub 2024 Aug 30.

Abstract

This study aims to assess and compare the prevalence of chronic diseases by the first-degree Family Medical History (FMH) and also explores the relationship between FMH and selected Non-communicable diseases (NCDs) among older adults in India. The present study collated secondary data from the Longitudinal Ageing Study in India (LASI, 2017-18). The eligible respondents for the analysis of this study were aged 45 years and above, where the final study sample consisted of 65,562 older adults across all Indian states and union territories. The LASI dataset collected responses on self-reported diseases: Hypertension, Stroke, Heart disease, Cancer, and Diabetes. These diseases have a high prevalence among the population and are considered in the present study. Along with disease status, respondents' first-degree relatives FMH were used to fulfil the objective. Descriptive statistical analysis and multiple logistic regression techniques were used to accomplish the objectives analysis. This approach was chosen due to the binary nature of our primary dependent variables. The study found that the prevalence of selected NCDs was considerably higher among older adults with FMH than those without FMH. It revealed that NCDs and the status of FMH of parents and siblings were significantly associated. Based on the multivariate-adjusted model, we found significantly higher odds for developing the NCDs when the respondents have FMH among at least one of the first-degree relative. The likelihood among those with FMH of having hypertension (AOR: 2.058), diabetes (AOR: 2.94), heart diseases (AOR: 2.39), stroke (AOR: 1.62) and cancer (AOR: 2.32) was higher compared to no FMH of respective diseases. Similarly, significant associations were observed according to the different stratification of the number of first-degree relatives FMH. The present study demonstrated that first-degree relatives FMH is indeed a dominant associated risk factor for chronic disease among the older adults of India. This study supports the promotion of a disease history tool for chronic disease prevention and early detection approaches as a valuable measure of NCD risk. Public health practitioners can take several steps to access FMH and incorporate FMH into public health programs for the screening of the risk population.

摘要

本研究旨在通过一级家族病史(FMH)评估和比较慢性病的患病率,并探讨印度老年人中FMH与选定的非传染性疾病(NCDs)之间的关系。本研究整理了来自印度纵向老龄化研究(LASI,2017 - 18年)的二手数据。本研究分析的合格受访者年龄在45岁及以上,最终研究样本包括印度所有邦和联邦属地的65562名老年人。LASI数据集收集了关于自我报告疾病的回答:高血压、中风、心脏病、癌症和糖尿病。这些疾病在人群中患病率很高,本研究对此进行了考量。除了疾病状况外,还利用受访者的一级亲属FMH来实现研究目标。采用描述性统计分析和多元逻辑回归技术来完成目标分析。选择这种方法是由于我们主要因变量的二元性质。研究发现,有FMH的老年人中选定的非传染性疾病患病率明显高于没有FMH的老年人。研究表明,非传染性疾病与父母和兄弟姐妹的FMH状况显著相关。基于多变量调整模型,我们发现当受访者在至少一位一级亲属中有FMH时,患非传染性疾病的几率显著更高。与相应疾病无FMH的人相比,有FMH的人患高血压(比值比:2.058)、糖尿病(比值比:2.94)、心脏病(比值比:2.39)、中风(比值比:1.62)和癌症(比值比:2.32)的可能性更高。同样,根据一级亲属FMH数量的不同分层也观察到了显著关联。本研究表明,一级亲属FMH确实是印度老年人慢性病的主要相关危险因素。本研究支持推广用于慢性病预防和早期检测方法的疾病史工具,作为非传染性疾病风险的一项重要措施。公共卫生从业者可以采取若干步骤来获取FMH,并将FMH纳入公共卫生项目以筛查高危人群。

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