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[中医药通过调控铁死亡途径干预生精上皮损伤的研究进展]

[Intervention of traditional Chinese medicine in spermatogenic epithelium injury by regulating the ferroptosis pathway: Advances in studies].

作者信息

Wei Jin-Tao, Ma Zi-Yang, Cao Jun, Zhang Pei-Hai

机构信息

Department of Urology and Andrology / Key Laboratory of Sichuan Province for TCM Regulation of Metabolic Diseases, The Affiliated Hospital of Chengdu University of Chinese Medicine, Chengdu, Sichuan 610075, China.

Taihe People's Hospital, Taihe, Anhui 236600, China.

出版信息

Zhonghua Nan Ke Xue. 2024 May;30(5):450-455.

Abstract

The incidence of male infertility has been increasing year by year, and one of the major causes is testicular spermatogenic epithelial injury, which affects the spermatogenic function of the testis. Ferroptosis is a novel mode of cell death and plays an important role in testicular cell injury. Some traditional Chinese medicines can intervene in the progression of testicular injury by regulating the ferroptosis pathway in testicular spermatogenic epithelia. This paper focuses on the effect of traditional Chinese drugs in regulating the ferroptosis pathway in testicular cells, and summarizes the advances in the studies of traditional Chinese medicines in the treatment of testicular spermatogenic epithelial injury, aiming to provide a theoretical basis for the selection of relevant medicines and their clinical application.

摘要

男性不育症的发病率逐年上升,其主要原因之一是睾丸生精上皮损伤,这会影响睾丸的生精功能。铁死亡是一种新型细胞死亡方式,在睾丸细胞损伤中起重要作用。一些中药可以通过调节睾丸生精上皮中的铁死亡途径来干预睾丸损伤的进展。本文重点探讨中药在调节睾丸细胞铁死亡途径方面的作用,并总结中药治疗睾丸生精上皮损伤的研究进展,旨在为相关药物的选择及其临床应用提供理论依据。

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