下咽浅表性鳞状细胞癌内镜切除的有效性及结果
Effectiveness and outcomes of endoscopic resection for superficial pharyngeal squamous cell carcinomas.
作者信息
Nakamura Naohiro, Sakagami Tomofumi, Shimizu Minaki, Suzuki Kensuke, Fujisawa Takuo, Shijimaya Takuya, Kobayashi Sanshiro, Takahashi Yu, Tahara Tomomitsu, Noda Yuri, Tsuta Koji, Naganuma Makoto
机构信息
Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Osaka, Japan.
Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Osaka, Japan.
出版信息
Head Neck. 2025 Feb;47(2):463-471. doi: 10.1002/hed.27924. Epub 2024 Aug 29.
BACKGROUND
With the development of endoscopic imaging, superficial pharyngeal squamous cell carcinoma can now be detected during routine endoscopy. Recently, the effectiveness of endoscopic resection for superficial pharyngeal squamous cell carcinoma have been reported.
METHODS
This study had a retrospective single-center design that included patients with superficial pharyngeal squamous cell carcinoma who underwent endoscopic resection. A total 47 patients with 53 lesions were analyzed.
RESULTS
En bloc and R0 resection rates were 83.0% and 56.6%. Local recurrence and cervical lymph node metastasis (CLNM) were detected in 1 and 3 patients during follow-up. The macroscopic type 0-I was an independent factor for CLNM. The 3-year cumulative incidence of metachronous pharyngeal squamous cell carcinoma following endoscopic resection was 33.0%, and the 5-year overall survival rate was 89.2%.
CONCLUSIONS
Endoscopic resection is an effective treatment for superficial pharyngeal squamous cell carcinomas, and the macroscopic type 0-I is a useful predictor of CLNM.
背景
随着内镜成像技术的发展，现在可以在常规内镜检查中发现浅表型咽鳞状细胞癌。最近，已有关于内镜切除治疗浅表型咽鳞状细胞癌有效性的报道。
方法
本研究采用回顾性单中心设计，纳入接受内镜切除的浅表型咽鳞状细胞癌患者。共分析了47例患者的53个病灶。
结果
整块切除率和R0切除率分别为83.0%和56.6%。随访期间，1例患者出现局部复发，3例患者出现颈部淋巴结转移（CLNM）。肉眼类型0-I是CLNM的独立危险因素。内镜切除术后异时性咽鳞状细胞癌的3年累积发生率为33.0%，5年总生存率为89.2%。
结论
内镜切除是治疗浅表型咽鳞状细胞癌的有效方法，肉眼类型0-I是CLNM的有用预测指标。
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