Department of Internal Medicine, Tsinghua University Hospital, Beijing, 100084, China.
Department of Cardiology, Beijing Chang Ping Hospital of Integrated Chinese and Western Medicine, Beijing, 102208, China.
Acta Gastroenterol Belg. 2024 Apr-Jun;87(2):294-303. doi: 10.51821/87.2.13044.
Functional dyspepsia is a common functional gastrointestinal disorder that is often challenging to treat. Psychotherapeutic interventions have been proposed as an alternative or adjunctive approach to conventional treatments, but their efficacy remains unclear.
This systematic review and meta-analysis aimed to evaluate the efficacy of psychotherapeutic interventions in the treatment of functional dyspepsia.
A comprehensive search of electronic databases was conducted, from inception to March 2023, for randomized controlled trials (RCTs) that evaluated the effects of psychotherapeutic interventions on patients with functional dyspepsia. The primary outcome measures were gastrointestinal symptoms, quality of life, depression, and anxiety. Data were extracted and analyzed using Review Manager 5.3 software. The risk of bias of the included studies was assessed using the Cochrane Risk of Bias tool.
Sixteen RCTs comprising 1550 patients with functional dyspepsia were included in the meta-analysis. The types of psychotherapeutic interventions used in the included studies were cognitive-behavioral therapy (CBT), hypnotherapy, and mindfulness-based stress reduction (MBSR). The control groups were usual care, placebo, supportive therapy, or no treatment. The meta-analysis showed that psychotherapeutic interventions had a significant effect on reducing gastrointestinal symptoms,depression and anxiety in patients with functional dyspepsia. However, no significant improvement was observed in the quality-of-life scores of patients who received psychotherapeutic interventions compared to those in the control group.
Psychotherapeutic interventions, such as CBT, hypnotherapy, and MBSR, could be a useful adjunct to conventional treatments for functional dyspepsia, as they were found to significantly reduce gastrointestinal symptoms and anxiety in patients. However, further studies are needed to assess the long-term effects and generalizability of these interventions.
功能性消化不良是一种常见的功能性胃肠道疾病，通常难以治疗。心理治疗干预已被提议作为传统治疗的替代或辅助方法，但它们的疗效仍不清楚。
本系统评价和荟萃分析旨在评估心理治疗干预治疗功能性消化不良的疗效。
从开始到 2023 年 3 月，全面检索电子数据库，以评估心理治疗干预对功能性消化不良患者的影响的随机对照试验（RCT）。主要结局指标是胃肠道症状、生活质量、抑郁和焦虑。使用 Review Manager 5.3 软件提取和分析数据。使用 Cochrane 偏倚风险工具评估纳入研究的偏倚风险。
荟萃分析纳入了 16 项 RCT，共 1550 例功能性消化不良患者。纳入研究中使用的心理治疗干预类型包括认知行为疗法（CBT）、催眠疗法和正念减压（MBSR）。对照组为常规护理、安慰剂、支持性治疗或不治疗。荟萃分析显示，心理治疗干预对减轻功能性消化不良患者的胃肠道症状、抑郁和焦虑有显著效果。然而，与对照组相比，接受心理治疗干预的患者的生活质量评分没有显著改善。
CBT、催眠疗法和 MBSR 等心理治疗干预可能是功能性消化不良常规治疗的有用辅助手段，因为它们被发现可显著减轻患者的胃肠道症状和焦虑。然而，需要进一步的研究来评估这些干预措施的长期效果和普遍性。
