Ong Ping Seung, Tan Lay Kim, Mat Hasnah, Tohar Najjah, Fathi Abdul Muhaimin, Kosenin Nia Maslia Atiera, Naim Muhammad Najmi Budiman, Redzuan Rafiqah Farhanah, Rani Nur Iffah Ab, Norhisham Najiha Arrissa, Sulaiman Wahinuddin
Rheumatology Unit, Department of Medicine, Hospital Raja Permaisuri Bainun, Jalan Raja Ashman Shah, Ipoh, Perak, Malaysia.
Sector for Biostatistics & Data Repository, Office of NIH Manager, National Institutes of Health, Ministry of Health Malaysia, Selangor, Malaysia.
Mediterr J Rheumatol. 2023 Aug 27;35(2):234-240. doi: 10.31138/mjr.050723.fla. eCollection 2024 Jun.
The aim of this study was to establish the incidence of liver abnormalities in psoriatic arthritis patients and identify the factors that contributed to this condition.
This is a longitudinal cohort study. Psoriatic arthritis (PsA) patients with liver enzymes abnormalities were identified. Our control group consisted of PsA patient from the same cohort who had no history of liver abnormalities. Factors associated with liver abnormalities were identified using univariate and multivariate analysis.
A total of 247 of PsA patients were included and out of those, 99 developed liver enzymes abnormalities. The mean age of the patients was 56 years old (±13.5) with 56.1% female and 39.4% Indian descendants. The univariate logistic regression demonstrated that disease duration of PsA (OR=1.06, 95% CI=1.01 - 1.10, p=0.012), diabetes mellitus (OR=2.16, 95% CI=1.26 - 3.70, 0.005) and non-alcoholic fatty liver disease (NAFLD) (OR=3.90, 95% CI = 1.44 - 10.53, p=0.007) were associated with abnormal liver function in PsA patients. No association was found with both conventional synthetic disease-modifying antirheumatic drugs or biologics.
Liver enzymes abnormalities in PsA patients were linked to disease duration, diabetes mellitus and NAFLD. For these high-risk populations, vigilant monitoring of liver function tests is vital for early detection and intervention.
本研究旨在确定银屑病关节炎患者肝脏异常的发生率，并找出导致这种情况的因素。
这是一项纵向队列研究。识别出肝功能酶异常的银屑病关节炎（PsA）患者。我们的对照组由同一队列中无肝脏异常病史的PsA患者组成。使用单因素和多因素分析来确定与肝脏异常相关的因素。
共纳入247例PsA患者，其中99例出现肝功能酶异常。患者的平均年龄为56岁（±13.5），女性占56.1%，印度裔占39.4%。单因素逻辑回归显示，PsA的病程（OR=1.06，95%CI=1.01 - 1.10，p=0.012）、糖尿病（OR=2.16，95%CI=1.26 - 3.70，p=0.005）和非酒精性脂肪性肝病（NAFLD）（OR=3.90，95%CI = 1.44 - 10.53，p=0.007）与PsA患者的肝功能异常有关。未发现与传统合成抗风湿药物或生物制剂有相关性。
PsA患者的肝功能酶异常与病程、糖尿病和NAFLD有关。对于这些高危人群，密切监测肝功能检查对于早期发现和干预至关重要。
