Chung Ryan S, Wong Stephanie, Lin Dechen, Kokot Niels C, Sinha Uttam K, Han Albert Y
Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Front Oncol. 2024 Aug 15;14:1425545. doi: 10.3389/fonc.2024.1425545. eCollection 2024.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer globally. Notably, human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is on the rise, accounting for 70% of all OPSCC cases. Persistent high-risk HPV infection is linked to various cancers, but HPV infection alone is not sufficient to cause cancer. Advances in next-generation sequencing have improved our understanding of changes in the human microbiome of cancerous environments. Yet, there remains a dearth of knowledge on the impact of HPV-microbiome crosstalk in HPV-positive OPSCC. In this review, we examine what is known about the oropharyngeal microbiome and the compositional shifts in this microbiome in HPV-positive OPSCC. We also review potential mechanisms of crosstalk between HPV and specific microorganisms. Additional research is needed to understand these interactions and their roles on cancer development and progression.
头颈部鳞状细胞癌（HNSCC）是全球第六大常见癌症。值得注意的是，人乳头瘤病毒（HPV）阳性的口咽鳞状细胞癌（OPSCC）呈上升趋势，占所有OPSCC病例的70%。持续的高危HPV感染与多种癌症相关，但仅HPV感染不足以引发癌症。下一代测序技术的进步增进了我们对癌性环境中人类微生物组变化的理解。然而，关于HPV与微生物组相互作用对HPV阳性OPSCC的影响，我们仍知之甚少。在这篇综述中，我们研究了关于口咽微生物组以及HPV阳性OPSCC中该微生物组组成变化的已知情况。我们还回顾了HPV与特定微生物之间相互作用的潜在机制。需要更多研究来了解这些相互作用及其在癌症发生和发展中的作用。
