Zapata P, Eyzaguirre C
Brain Res. 1985 Apr 1;331(1):39-50. doi: 10.1016/0006-8993(85)90713-9.
Simultaneous recordings of focal slow potentials (sVs) and chemosensory discharges were made from cat carotid body-nerve preparations in situ. Chemoreceptor stimulants (100% N2, asphyxia, NaCN, ACh and nicotine), and depressants (100% O2, spontaneous gasps and dopamine) changed receptor polarization. sVs evoked by stimulants had a negative polarity whereas depressants elicited positive deflections. There was a direct correlation between maximal frequency of chemosensory discharges and peak sV amplitude when NaCN injections or N2 inhalation were used. However, cholinergic agents, dopamine and substance P evoked sVs which lacked correlation in time-course, amplitude or polarity with changes in sensory frequency. After a 6-day carotid nerve crush, different stimuli still evoked sVs even in the absence of sensory discharges. Both sVs and chemosensory discharges were abolished after 1 h ischemia produced by ligature of carotid body blood vessels. Thus, sVs from carotid body chemoreceptors probably include a neuronal component (the generator potential) directly responsible for the origin of chemosensory discharges, and a non-neuronal component (receptor or secretory potentials) probably originating in glomus and/or sustentacular cells.
在原位对猫的颈动脉体 - 神经标本同时记录局灶性慢电位（sVs）和化学感受性放电。化学感受器兴奋剂（100% N₂、窒息、NaCN、乙酰胆碱和尼古丁）以及抑制剂（100% O₂、自发性喘息和多巴胺）改变感受器极化。兴奋剂诱发的sVs具有负极性，而抑制剂引起正向偏转。当使用NaCN注射或吸入N₂时，化学感受性放电的最大频率与sV峰值幅度之间存在直接相关性。然而，胆碱能药物、多巴胺和P物质诱发的sVs在时间进程、幅度或极性上与感觉频率的变化缺乏相关性。在颈动脉神经挤压6天后，即使在没有感觉放电的情况下，不同刺激仍能诱发sVs。在结扎颈动脉体血管导致1小时缺血后，sVs和化学感受性放电均被消除。因此，来自颈动脉体化学感受器的sVs可能包括直接负责化学感受性放电起源的神经元成分（发生器电位），以及可能起源于球细胞和/或支持细胞的非神经元成分（感受器或分泌电位）。
