Peng Hao, Ran Xuehui, Yang Xia, Zhou Guoyu, Lin Xiaoxi, Shen Lingyue, Wu Xianglei
Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Center of Head and Neck Oncology Clinical and Translational Science, Shanghai, China.
J Cosmet Dermatol. 2024 Dec;23(12):3986-3992. doi: 10.1111/jocd.16552. Epub 2024 Aug 30.
Atrophic acne scars (AAS) are disfiguring and permanent changes caused by inflammatory acne. Fractional carbon dioxide is a common ablative device used to treat this condition. However, issues such as unclear effectiveness, frequent treatments, and potential side effects exist. In recent years, recombinant human epidermal growth factor (rhEGF) has also been frequently reported for its application in the treatment of acne scars.
To explore the potential synergistic effect of fractional carbon dioxide laser combined with rhEGF in AAS treatment.
We enrolled 15 patients with AAS. They received fractional carbon dioxide laser treatment and were then randomly assigned to receive either rhEGF or a placebo on one side of the face. The procedure was repeated three times, and the results were evaluated using the échelle d'évaluation clinique des cicatrices d'acné (ECCA) score and analyzed using the CBS camera system, 3D analysis (3DMD). Reflectance confocal microscopy (RCM) examination was also conducted.
Both sides exhibited significant improvement in the appearance of the acne scars after treatment, as confirmed by the ECCA score, 3DMD data, and CBS texture score. On the rhEGF-treated side, the pore number and epidermal pigment area significantly improved as compared to the control side, whereas no significant differences were observed in the other data. Under RCM, a significant increase in epidermal thickness and appearance of reticular collagen fibers in the dermal layer after treatment was observed.
Compared to the sole use of laser, the combination of fractional carbon dioxide laser and rhEGF does not significantly enhance scar therapeutic effects. However, it does shorten the recovery period after laser treatment and improves the pore appearance.
萎缩性痤疮瘢痕（AAS）是由炎性痤疮引起的毁容性永久性改变。二氧化碳点阵激光是治疗这种疾病常用的一种剥脱性设备。然而，存在疗效不明确、治疗频繁以及潜在副作用等问题。近年来，重组人表皮生长因子（rhEGF）在痤疮瘢痕治疗中的应用也屡有报道。
探讨二氧化碳点阵激光联合rhEGF治疗AAS的潜在协同作用。
我们纳入了15例AAS患者。他们接受了二氧化碳点阵激光治疗，然后随机分配在面部一侧接受rhEGF或安慰剂治疗。该操作重复3次，结果使用痤疮瘢痕临床评估量表（ECCA）评分进行评估，并使用CBS摄像系统、三维分析（3DMD）进行分析。还进行了反射式共聚焦显微镜（RCM）检查。
经ECCA评分、3DMD数据和CBS纹理评分证实，治疗后两侧痤疮瘢痕外观均有显著改善。与对照组相比，rhEGF治疗侧的毛孔数量和表皮色素面积显著改善，而其他数据未见显著差异。在RCM下，观察到治疗后表皮厚度显著增加，真皮层出现网状胶原纤维。
与单纯使用激光相比，二氧化碳点阵激光联合rhEGF并没有显著增强瘢痕治疗效果。然而，它确实缩短了激光治疗后的恢复期，并改善了毛孔外观。
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