Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Rheumatology Research Unit, Department of Clinical Medicine and Surgery, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Clin Exp Rheumatol. 2024 Nov;42(11):2280-2287. doi: 10.55563/clinexprheumatol/p2nclz. Epub 2024 Aug 20.
Psoriatic arthritis (PsA) is an immune-inflammatory disease occurring in a subgroup of patients suffering from psoriasis. Dactylitis is recognised as a hallmark of PsA, being present in about 50% of patients. This article gives an overview of the complexity of psoriatic dactylitis, looking at clinical aspects as well as pathogenetic aspects and subsequent insights into treatment strategies.
The review focuses on the main evidence on pathogenesis, clinical features, and management of psoriatic dactylitis.
In recent years, more studies have focused their attention on dactylitis in PsA patients, leading to a greater understanding of its pathogenesis and clinical presentation and to a growing expansion of the therapeutic armamentarium. Dactylitis is frequently associated with more severe PsA phenotype, often representing the initial feature of the disease. Its prompt recognition can be key for addressing early diagnosis and therapy of PsA, thus leading to better clinical and radiographic outcomes.
There has been considerable progress in understanding psoriatic dactylitis, but major challenges remain. Although there has been a recent expansion in the therapeutic armamentarium for psoriatic dactylitis, there is still a paucity of evidence on a precision approach to this manifestation.
银屑病关节炎（PsA）是一种免疫炎症性疾病，发生在患有银屑病的患者亚组中。指炎是银屑病关节炎的一个标志，约 50%的患者存在该症状。本文概述了复杂性银屑病关节炎的发病机制，包括临床和发病机制方面，以及随后对治疗策略的深入了解。
本综述重点关注银屑病关节炎患者的发病机制、临床特征和管理的主要证据。
近年来，越来越多的研究关注银屑病关节炎患者的指炎，从而对其发病机制和临床表现有了更深入的了解，并不断扩大治疗手段。指炎常与更严重的银屑病关节炎表型相关，通常是疾病的初始特征。早期识别对于早期诊断和治疗银屑病关节炎至关重要，从而获得更好的临床和影像学结果。
尽管在理解银屑病关节炎方面取得了相当大的进展，但仍面临重大挑战。尽管针对银屑病关节炎的治疗手段最近有所扩大，但针对这种表现形式的精准治疗方法仍缺乏证据。
