Department of Biology, Indiana University, Bloomington, Indiana, USA.
Infect Immun. 2024 Oct 15;92(10):e0005924. doi: 10.1128/iai.00059-24. Epub 2024 Aug 30.
Intracellular bacteria use secreted effector proteins to modify host biology and facilitate infection. For many of these microbes, a particular eukaryotic domain-the ankyrin repeat (ANK)-plays a central role in specifying the host proteins and pathways targeted by the microbe. While we understand much of how some ANKs function in model organisms like and , the understudied species harbor many proteins with ANKs, some of which play critical roles during infection. This minireview is meant to organize and summarize the research progress made in understanding some of these ANKs as well as document some of the techniques that have driven much of this progress.
细胞内细菌利用分泌的效应蛋白来修饰宿主生物学并促进感染。对于许多这些微生物，一个特定的真核结构域——锚蛋白重复（ANK）——在确定微生物靶向的宿主蛋白和途径方面起着核心作用。虽然我们了解了一些在 和 等模式生物中 ANK 的功能，但在研究较少的 物种中，有许多带有 ANK 的蛋白质，其中一些在感染过程中起着关键作用。这篇迷你评论旨在组织和总结在理解其中一些 ANK 方面所取得的研究进展，并记录推动这一进展的一些技术。
