Ruan Zhaoyang, Wang Dongying, He Xiaoxia, Jiang Meihua, Zeng Yingxin, Liu Ling, Jiang Haibo
Altern Ther Health Med. 2024 Aug 30.
The neutrophil to lymphocyte ratio (NLR) or platelet to lymphocyte ratio (PLR) is an inflammation marker of acute ischemic stroke, but the predictive value of NLR and PLR before and after thrombolysis for short-term prognosis in acute ischemic stroke patients after thrombolysis remains largely obscure. This study attempts to clarify the predictive value of NLR and PLR before and after thrombolysis for short-term prognosis in acute ischemic stroke patients after thrombolysis.
A retrospective study was carried out in the Affiliated Hospital of Hangzhou Normal University involving 120 patients visiting the neurology department of our hospital from May 2019 to October 2022 and meeting the selection criteria. The participants were assigned to the good prognosis group and the poor prognosis group based on the modified Rankin scale score. Laboratory data collected include NLR and PLR at admission as well as NLR and PLR collected from venous blood within 24 h after thrombolysis.
Age, hyperlipidemia, atrial fibrillation, rheumatic heart disease, and National Institutes of Health Stroke Scale (NIHSS) scores after thrombolysis depicted statistical significance between both groups (P < .05). Hyperlipidemia, atrial fibrillation, and NIHSS scores before thrombolysis were independent risk elements for adverse prognosis (P < .05). NLR and PLR before and after thrombolysis in the poor prognosis group depicted an elevation relative to that in the good prognosis group (P < .05). The area under the curve of NLR or PLR predicting adverse prognosis after thrombolysis depicted an elevation relative to that before thrombolysis (P < .05).
The predictive value of NLR and PLR post-thrombolysis for short-term prognosis in acute ischemic stroke patients depicts an elevation relative to pre-thrombolysis; our study provides effective predictive indicators for short-term prognosis in acute ischemic stroke patients.
中性粒细胞与淋巴细胞比值（NLR）或血小板与淋巴细胞比值（PLR）是急性缺血性卒中的炎症标志物，但溶栓前后NLR和PLR对急性缺血性卒中患者溶栓后短期预后的预测价值仍不清楚。本研究旨在阐明溶栓前后NLR和PLR对急性缺血性卒中患者溶栓后短期预后的预测价值。
在杭州师范大学附属医院进行了一项回顾性研究，纳入了2019年5月至2022年10月期间到我院神经内科就诊且符合入选标准的120例患者。根据改良Rankin量表评分将参与者分为预后良好组和预后不良组。收集的实验室数据包括入院时的NLR和PLR，以及溶栓后24小时内从静脉血中采集的NLR和PLR。
两组在年龄、高脂血症、心房颤动、风湿性心脏病以及溶栓后的美国国立卫生研究院卒中量表（NIHSS）评分方面存在统计学差异（P < 0.05）。高脂血症、心房颤动和溶栓前的NIHSS评分是不良预后的独立危险因素（P < 0.05）。预后不良组溶栓前后的NLR和PLR均高于预后良好组（P < 0.05）。溶栓后NLR或PLR预测不良预后的曲线下面积相对于溶栓前有所升高（P < 0.05）。
溶栓后NLR和PLR对急性缺血性卒中患者短期预后的预测价值相对于溶栓前有所提高；我们的研究为急性缺血性卒中患者的短期预后提供了有效的预测指标。
