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杂交手术治疗症状性慢性颈内动脉闭塞:单中心经验。

Hybrid Surgery for symptomatic chronic internal carotid artery occlusion: a single-center experience.

机构信息

Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.

Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

出版信息

Acta Neurochir (Wien). 2024 Aug 30;166(1):355. doi: 10.1007/s00701-024-06250-4.

Abstract

BACKGROUND

Patients with symptomatic chronic internal carotid artery occlusion (ICAO) face a high risk of recurrent stroke despite receiving aggressive medical therapy. This study aimed to evaluate the effectiveness and safety of hybrid surgery in treating symptomatic chronic ICAO.

METHODS

This retrospective case series was conducted at a single center. From January 2019 to December 2022, patients with symptomatic chronic ICAO who underwent hybrid surgery were included. We collected baseline data, lesion characteristics, revascularization rates, perioperative complications, and follow-up outcomes.

RESULTS

The study enrolled 27 patients, comprising 22 males and 5 females, with symptomatic chronic ICAO. The hybrid surgery achieved a technical success rate of 100% for revascularization (n = 27), with a perioperative complication rate of 14.8% (n = 4). Following a median follow-up of 6.0 months (IQR, 4-10), 21 patients underwent a DSA or CT angiography reexamination, confirming a vascular patency rate of 90.5% (n = 19). One patient required surgery for severe in-stent restenosis, and another experienced asymptomatic occlusion. Clinical follow-ups were conducted for all 26 patients; no new strokes were reported in the qualifying artery territory, with 13 patients scoring 0, 12 scoring 1, and 1 scoring 2 on the mRS.

CONCLUSION

Although hybrid surgery represent a promising option for treating chronic ICAO, they are also associated with a relatively high incidence of treatment-related complications. The application of composite surgery should be based on standardized technical guidelines and the careful selection of patients who are genuinely at high risk for recurrent strokes.

摘要

背景

尽管接受了积极的药物治疗,有症状的慢性颈内动脉闭塞(ICAO)患者仍面临着较高的卒中复发风险。本研究旨在评估杂交手术治疗有症状的慢性 ICAO 的有效性和安全性。

方法

这是一项单中心回顾性病例系列研究。自 2019 年 1 月至 2022 年 12 月,对接受杂交手术治疗的有症状慢性 ICAO 患者进行了研究。我们收集了基线数据、病变特征、再通率、围手术期并发症和随访结果。

结果

研究纳入了 27 例有症状慢性 ICAO 患者,其中男性 22 例,女性 5 例。杂交手术的再通率达到了 100%(n=27),围手术期并发症发生率为 14.8%(n=4)。术后中位随访时间为 6.0 个月(IQR,4-10),21 例患者接受了 DSA 或 CT 血管造影复查,血管通畅率为 90.5%(n=19)。1 例患者因严重支架内再狭窄而行手术治疗,另 1 例患者发生无症状性闭塞。对所有 26 例患者进行了临床随访,在符合条件的动脉区域未发生新的卒中,13 例患者 mRS 评分为 0,12 例患者评分为 1,1 例患者评分为 2。

结论

尽管杂交手术是治疗慢性 ICAO 的一种有前途的选择,但它们也与相对较高的治疗相关并发症发生率相关。复合手术的应用应基于标准化的技术指南,并仔细选择那些真正存在复发性卒中高风险的患者。

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