Department of Chemistry, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.
Discipline of Radiology, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.
J Huntingtons Dis. 2024;13(3):279-299. doi: 10.3233/JHD-240045.
Structural magnetic resonance imaging (MRI) is a powerful tool to visualize 3D neuroanatomy and assess pathology and disease progression in neurodegenerative disorders such as Huntington's disease (HD). The development of mouse models of HD that reproduce many of the psychiatric, motor and cognitive impairments observed in human HD has improved our understanding of the disease and provided opportunities for testing novel therapies. Similar to the clinical scenario, MRI of mouse models of HD demonstrates onset and progression of brain pathology. Here, we provided an overview of the articles that used structural MRI in mouse models of HD to date, highlighting the differences between studies and models and describing gaps in the current state of knowledge and recommendations for future studies.
结构磁共振成像（MRI）是一种强大的工具，可用于可视化 3D 神经解剖结构，并评估神经退行性疾病（如亨廷顿病（HD））中的病理学和疾病进展。开发出能够重现人类 HD 中观察到的许多精神、运动和认知障碍的 HD 小鼠模型，这提高了我们对该疾病的认识，并为测试新疗法提供了机会。与临床情况类似，HD 小鼠模型的 MRI 显示出脑部病理学的发生和进展。在这里，我们概述了迄今为止使用结构 MRI 研究 HD 小鼠模型的文章，重点介绍了研究和模型之间的差异，并描述了当前知识状态的差距以及对未来研究的建议。
