Hentosh Samantha, Zhu Liang, Patino Jorge, Furr J Weldon, Rocha Natalia P, Furr Stimming Erin
McGovern Medical School, The University of Texas Health Science Center (UTHealth) Houston Texas USA.
Department of Internal Medicine McGovern Medical School, The University of Texas Health Science Center (UTHealth) Houston Texas USA.
Mov Disord Clin Pract. 2021 Mar 8;8(3):420-426. doi: 10.1002/mdc3.13178. eCollection 2021 Apr.
Identifying sex-related differences is critical for enhancing our understanding of factors that may impact prognosis and advance treatments in Huntington's disease (HD).
To investigate if sex-related differences exist in clinical HD.
Longitudinal study of the Enroll-HD database. Manifest HD patients were included in the analysis (N = 8401). Linear mixed models were used to assess motor, behavioral, and cognitive functioning over a series of four annual visits, and compared male and female HD gene carriers.
HD patients showed significant sex-dependent differences in motor, cognitive, and behavioral symptoms. Both sexes had worsened motor symptoms over the course of four visits, but there was a significant disparity between sexes, with females consistently presenting with more symptoms than males. For behavioral symptoms, specifically depressive symptoms, females had significantly more depressive symptoms, although self-reported symptoms in both sexes became less severe throughout time.
Our analyses suggest that women have worse symptoms than men during the course of HD.
识别性别相关差异对于增进我们对可能影响亨廷顿舞蹈症（HD）预后和推进治疗的因素的理解至关重要。
调查临床HD中是否存在性别相关差异。
对Enroll-HD数据库进行纵向研究。分析纳入有明显症状的HD患者（N = 8401）。采用线性混合模型评估在连续四次年度访视期间的运动、行为和认知功能，并比较男性和女性HD基因携带者。
HD患者在运动、认知和行为症状方面表现出显著的性别依赖性差异。在四次访视过程中，两性的运动症状均有所恶化，但两性之间存在显著差异，女性始终比男性表现出更多症状。对于行为症状，特别是抑郁症状，女性有明显更多的抑郁症状，尽管随着时间推移两性自我报告的症状都有所减轻。
我们的分析表明，在HD病程中女性的症状比男性更严重。
