Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Cancer Cell. 2024 Sep 9;42(9):1489-1491. doi: 10.1016/j.ccell.2024.08.003. Epub 2024 Aug 29.
Neoadjuvant chemoradiotherapy has been a mainstay of the treatment of locally advanced rectal cancer. Programmed cell death protein 1 (PD-1) blockade therapy has demonstrated efficacy in combination with radiation. In this issue, Xiao et al. demonstrate promising efficacy with the addition of PD-1 blockade to neoadjuvant therapy for mismatch-repair proficient rectal cancer.
新辅助放化疗一直是局部晚期直肠癌治疗的主要手段。程序性死亡蛋白 1（PD-1）阻断疗法与放疗联合显示出疗效。在本期杂志中，Xiao 等人证明了在错配修复功能正常的直肠癌新辅助治疗中加入 PD-1 阻断的疗效有很大的潜力。
