Shoupe D, Lobo R A
Fertil Steril. 1985 Apr;43(4):549-53.
The administration of gonadotropin-releasing hormone (GnRH) has been shown to stimulate prolactin (PRL) release under certain conditions. The authors compared PRL responses after GnRH in normoprolactinemic patients with the polycystic ovary syndrome (PCO) with those of normal ovulatory women in the follicular phase. Seven of 15 patients had a significant increase in PRL after GnRH, whereas none of the control subjects had a positive response. After 1 week of oral L-dopa, the responders no longer exhibited this positive response. Baseline PRL levels in responding patients with PCO were similar to levels in control subjects, whereas nonresponding patients with PCO had higher PRL levels. Baseline follicle-stimulating hormone (FSH)/luteinizing hormone (LH) ratios were higher in patients with a positive response. The positive PRL response after GnRH was not correlated with baseline serum LH, the LH/FSH ratio, delta maximum LH responses, serum testosterone (T), unbound T, or baseline PRL. The positive response correlated positively with serum levels of unbound estradiol (P less than 0.05) and serum unbound estradiol/unbound T ratios (P less than 0.01). These data suggest that under certain conditions a subgroup of patients with PCO may demonstrate a positive PRL response after GnRH. Dopamine, gonadotropins, and estrogen may play a role in this interaction.
在某些情况下，促性腺激素释放激素（GnRH）的给药已被证明能刺激催乳素（PRL）释放。作者比较了多囊卵巢综合征（PCO）的正常催乳素血症患者与卵泡期正常排卵女性在给予GnRH后PRL的反应。15名患者中有7名在给予GnRH后PRL显著升高，而对照组中无一例有阳性反应。口服左旋多巴1周后，有反应者不再表现出这种阳性反应。有反应的PCO患者的基线PRL水平与对照组相似，而无反应的PCO患者的PRL水平更高。有阳性反应的患者基线促卵泡生成素（FSH）/促黄体生成素（LH）比值更高。GnRH后PRL阳性反应与基线血清LH、LH/FSH比值、最大LH反应增量、血清睾酮（T）、游离T或基线PRL均无相关性。阳性反应与血清游离雌二醇水平呈正相关（P<0.05），与血清游离雌二醇/游离T比值呈正相关（P<0.01）。这些数据表明，在某些情况下，PCO患者的一个亚组在给予GnRH后可能表现出PRL阳性反应。多巴胺、促性腺激素和雌激素可能在这种相互作用中起作用。
