SSGU-CD: A combined semantic and structural information graph U-shaped network for document-level Chemical-Disease interaction extraction.

Document-level interaction extraction for Chemical-Disease is aimed at inferring the interaction relations between chemical entities and disease entities across multiple sentences. Compared with sentence-level relation extraction, document-level relation extraction can capture the associations between different entities throughout the entire document, which is found to be more practical for biomedical text information. However, current biomedical extraction methods mainly concentrate on sentence-level relation extraction, making it difficult to access the rich structural information contained in documents in practical application scenarios. We put forward SSGU-CD, a combined Semantic and Structural information Graph U-shaped network for document-level Chemical-Disease interaction extraction. This framework effectively stores document semantic and structure information as graphs and can fuse the original context information of documents. Using the framework, we propose a balanced combination of cross-entropy loss function to facilitate collaborative optimization among models with the aim of enhancing the ability to extract Chemical-Disease interaction relations. We evaluated SSGU-CD on the document-level relation extraction dataset CDR and BioRED, and the results demonstrate that the framework can significantly improve the extraction performance.