Department of Neurology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, Jiangsu, China.
Department of Central Laboratory, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, Jiangsu, China.
Neurosci Lett. 2024 Oct 15;841:137952. doi: 10.1016/j.neulet.2024.137952. Epub 2024 Aug 28.
The removal of axonal and myelin debris by macrophages is crucial for safeguarding nerves and facilitating functional recuperation in cerebral ischemic stroke. However, the physiological function of macrophage scavenger receptor 1 (MSR1) in ischemic white matter injury remains poorly de-fined. In this study, we observed an elevation in Msr1 expression levels in mice with experimental cerebral ischemic stroke. Msr 1-deficient (Msr1-/-) mice exhibited exacerbated behavioral deficits and aggravated white matter injury after ischemic stroke. Furthermore, the overexpression of Msr1 led to an increase in the phosphorylation of Akt via Hrh1, which in turn expedited the clearance of myelin debris through the PI3K/AKT pathway. In conclusion, our findings underscore the essential role of MSR1 in microglial phagocytosis and its ability to mitigate ischemic white matter injury in cerebral ischemic stroke.
巨噬细胞清除轴突和髓磷脂碎片对于保护神经和促进脑缺血性中风的功能恢复至关重要。然而，巨噬细胞清道夫受体 1（MSR1）在缺血性白质损伤中的生理功能仍未得到明确界定。在本研究中，我们观察到实验性脑缺血性中风小鼠中 Msr1 表达水平升高。Msr1 缺陷（Msr1-/-）小鼠在缺血性中风后表现出更严重的行为缺陷和加重的白质损伤。此外，Msr1 的过表达通过 Hrh1 导致 Akt 的磷酸化增加，从而通过 PI3K/AKT 途径加速髓磷脂碎片的清除。总之，我们的研究结果强调了 MSR1 在小胶质细胞吞噬作用中的重要作用及其减轻脑缺血性中风中缺血性白质损伤的能力。
