Yi Xuan, Hussain Irshad, Zhang Peng, Xiao Chunsheng
Key Laboratory of Polymer Ecomaterials, Jilin Biomedical Polymers Engineering Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P.R. China.
Department of Chemistry and Chemical Engineering, SBA School of Science & Engineering, Lahore University of Management Sciences (LUMS). DHA, Lahore, 54792, Pakistan.
Chembiochem. 2024 Dec 16;25(24):e202400596. doi: 10.1002/cbic.202400596. Epub 2024 Oct 23.
Nucleus is the central regulator of cells that controls cell proliferation, metabolism, and cell cycle, and is considered the most important organelle in cells. The precision medicine that can achieve nuclear targeting has achieved good therapeutic effects in anti-tumor therapy. However, the presence of biological barriers such as cell membranes and nuclear membranes in cells limit the delivery of therapeutic agents to the nucleus. Therefore, developing effective nuclear-targeting drug delivery strategies is particularly important. Nuclear-targeting peptides are a class of functional peptides that can penetrate cell membranes and target the nucleus. They mainly recognize and bind to the nuclear transport molecules (such as Importin-α/β) and transport the therapeutic agents to the nucleus through nuclear pore complexes (NPC). This review summarizes the most recent developments of strategies for anti-tumor therapy utilizing nuclear-targeting peptides, which will ultimately contribute to the development of more effective nuclear-targeting strategies to achieve better anti-tumor outcomes.
细胞核是细胞的中央调节者，控制细胞增殖、代谢和细胞周期，被认为是细胞中最重要的细胞器。能够实现核靶向的精准医学在抗肿瘤治疗中取得了良好的治疗效果。然而，细胞中细胞膜和核膜等生物屏障的存在限制了治疗剂向细胞核的递送。因此，开发有效的核靶向药物递送策略尤为重要。核靶向肽是一类能够穿透细胞膜并靶向细胞核的功能性肽。它们主要识别并结合核转运分子（如输入蛋白-α/β），并通过核孔复合体（NPC）将治疗剂转运至细胞核。本综述总结了利用核靶向肽进行抗肿瘤治疗策略的最新进展，这最终将有助于开发更有效的核靶向策略以实现更好的抗肿瘤效果。
