Institute of Mental Health Education, Anhui Normal University, Wuhu, 241000, China.
School of Educational Science, Anhui Normal University, Wuhu, 241000, China.
BMC Geriatr. 2024 Aug 30;24(1):723. doi: 10.1186/s12877-024-05290-w.
This study explores whether the impact of environmental factors (community services usage, CSU) on geriatric depression is mediated by psychological resilience and moderated by the COMT (catechol-O-methyltransferase) gene val158met polymorphism.
The data consists of 13,512 entries from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) collected in the years 2008, 2011, 2014, and 2018. The study employed a Random Intercept Cross-Lagged Panel Model (RI-CLPM) to examine the relationship between CSU and geriatric depression, including the mediating effect of psychological resilience and the moderating role of the comt gene val158met gene polymorphism in this relationship.
Lower CSU at earlier assessments were significantly associated with more severe geriatric depression in subsequent evaluations.Psychological resilience was found to partially mediate the relationship between CSU and depression.Differential impacts were observed among various gene genotypes; specifically, the val genotype demonstrated a significantly greater influence of CSU on subsequent psychological resilience and on subsequent depression compared to the met genotype.
Enhancement in CSU can predict subsequent geriatric depression. The relationship between the CSU and depression can be mediated by psychological resilience, with genetics modulating the pathway from CSU through psychological resilience to depression. Multidisciplinary interventions focused on enhancing community service quality, boosting psychological resilience, and mitigating depression are likely to benefit the older adults's emotional and psychological well-being.
本研究旨在探讨环境因素（社区服务使用情况，CSU）对老年抑郁的影响是否通过心理弹性来介导，以及 COMT（儿茶酚-O-甲基转移酶）基因 val158met 多态性来调节。
本研究的数据来自中国老年健康长寿跟踪调查（CLHLS），收集于 2008 年、2011 年、2014 年和 2018 年。研究采用随机截距交叉滞后面板模型（RI-CLPM）来检验 CSU 与老年抑郁之间的关系，包括心理弹性的中介作用和 comt 基因 val158met 基因多态性在该关系中的调节作用。
早期评估中较低的 CSU 与随后评估中更严重的老年抑郁显著相关。心理弹性被发现部分介导了 CSU 与抑郁之间的关系。不同的基因基因型表现出不同的影响；具体来说，val 基因型与 met 基因型相比，CSU 对随后的心理弹性和随后的抑郁有更大的影响。
CSU 的增强可以预测随后的老年抑郁。CSU 与抑郁之间的关系可以通过心理弹性来介导，而遗传学则调节了 CSU 通过心理弹性到抑郁的途径。以提高社区服务质量、增强心理弹性和减轻抑郁为重点的多学科干预措施可能有益于老年人的情绪和心理健康。
