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Is HBV RNA a new endpoint of HBV cure?

作者信息

Chan Henry Lik Yuen

机构信息

Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.

Department of Internal Medicine, Union Hospital, Hong Kong.

出版信息

Saudi J Gastroenterol. 2024 Sep 1;30(5):273-274. doi: 10.4103/sjg.sjg_274_24. Epub 2024 Sep 2.

DOI:10.4103/sjg.sjg_274_24
PMID:39215476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11534194/
Abstract
摘要

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本文引用的文献

1
Elevated Hepatitis B virus RNA levels in hepatocellular carcinoma patients compared to cirrhotic individuals: A propensity score matched analysis.与肝硬化个体相比，肝癌患者的乙型肝炎病毒 RNA 水平升高：一项倾向评分匹配分析。
Saudi J Gastroenterol. 2024 Sep 1;30(5):294-301. doi: 10.4103/sjg.sjg_16_24. Epub 2024 Jul 24.
2
Quantification of circulating HBV RNA expressed from intrahepatic cccDNA in untreated and NUC treated patients with chronic hepatitis B.定量检测未经核苷（酸）类似物治疗和治疗的慢性乙型肝炎患者肝内cccDNA 转录的 HBV RNA。
Gut. 2024 Mar 7;73(4):659-667. doi: 10.1136/gutjnl-2023-330644.
3
Baseline serum HBV RNA is associated with the risk of hepatitis flare after stopping nucleoside analog therapy in HBeAg-negative participants.基线血清 HBV RNA 与 HBeAg 阴性患者停止核苷类似物治疗后肝炎发作的风险相关。
Hepatol Commun. 2023 Jul 17;7(8). doi: 10.1097/HC9.0000000000000188. eCollection 2023 Aug 1.
4
Guidance on treatment endpoints and study design for clinical trials aiming to achieve cure in chronic hepatitis B and D: Report from the 2022 AASLD-EASL HBV-HDV Treatment Endpoints Conference.旨在实现慢性乙型肝炎和丁型肝炎治愈的临床试验治疗终点和研究设计指南：2022 年美国肝病研究学会-欧洲肝脏研究学会乙型肝炎-丁型肝炎治疗终点会议报告。
J Hepatol. 2023 Nov;79(5):1254-1269. doi: 10.1016/j.jhep.2023.06.002. Epub 2023 Jun 21.
5
Measuring hepatitis B pgRNA stability using an updated automated HBV pgRNA assay with increased sensitivity.使用一种经过更新的、灵敏度更高的自动化 HBV pgRNA 检测方法来测量乙型肝炎 pgRNA 的稳定性。
Hepatol Commun. 2023 Mar 17;7(4). doi: 10.1097/HC9.0000000000000099. eCollection 2023 Apr 1.
6
How to achieve functional cure of HBV: Stopping NUCs, adding interferon or new drug development?如何实现乙肝功能性治愈：停止核苷（酸）类似物，加用干扰素或开发新药？
J Hepatol. 2022 Jun;76(6):1249-1262. doi: 10.1016/j.jhep.2021.11.024.
7
Performance of the cobas® HBV RNA automated investigational assay for the detection and quantification of circulating HBV RNA in chronic HBV patients.cobas® HBV RNA 自动化检测分析用于检测和定量慢性 HBV 患者循环 HBV RNA 的性能。
J Clin Virol. 2022 Jun;150-151:105150. doi: 10.1016/j.jcv.2022.105150. Epub 2022 Apr 4.
8
Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy.长期核苷（酸）治疗后，HBV DNA 低于检测下限的慢性乙型肝炎患者中持续的病毒复制和传染性病毒的产生。
PLoS One. 2022 Apr 1;17(4):e0262516. doi: 10.1371/journal.pone.0262516. eCollection 2022.
9
Association of Serum Hepatitis B Virus RNA With Hepatocellular Carcinoma Risk in Chronic Hepatitis B Patients Under Nucleos(t)ide Analogues Therapy.血清乙型肝炎病毒 RNA 与核苷（酸）类似物治疗慢性乙型肝炎患者肝细胞癌风险的相关性。
J Infect Dis. 2022 Sep 13;226(5):881-890. doi: 10.1093/infdis/jiab597.
10
HBV RNA Profiles in Patients With Chronic Hepatitis B Under Different Disease Phases and Antiviral Therapy.慢性乙型肝炎不同疾病阶段和抗病毒治疗患者的 HBV RNA 谱。
Hepatology. 2021 Jun;73(6):2167-2179. doi: 10.1002/hep.31616.