Hendriks A Emile J, Burns Charlotte, Fleming Ben, Harper Ines, Hook Elizabeth, Armstrong Ruth, Pamporaki Christina, Eisenhofer Graeme, Murray Matthew J, Casey Ruth T
Department of Paediatric Endocrinology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
J Clin Endocrinol Metab. 2025 Feb 18;110(3):855-862. doi: 10.1210/clinem/dgae603.
Catecholamine-producing tumors of childhood include neuroblastic tumors, phaeochromocytoma, and paraganglioma (PPGL). PPGL and neuroblastic tumors can arise in similar anatomical locations and clinical presentations can overlap, resulting in diagnostic challenges. Distinguishing between these tumor types is critical as management and long-term surveillance strategies differ depending on the diagnosis. Herein we describe 2 clinical cases and illustrate key considerations in the diagnostic workup of a neuroblastoma vs PPGL for patients presenting with adrenal, pelvic, and retroperitoneal masses in childhood.
儿童期产生儿茶酚胺的肿瘤包括神经母细胞瘤、嗜铬细胞瘤和副神经节瘤（PPGL）。PPGL和神经母细胞瘤可发生于相似的解剖部位，临床表现可能重叠，从而带来诊断挑战。区分这些肿瘤类型至关重要，因为治疗和长期监测策略会因诊断不同而有所差异。在此，我们描述2例临床病例，并阐述儿童期出现肾上腺、盆腔和腹膜后肿块的患者在神经母细胞瘤与PPGL诊断检查中的关键注意事项。
