College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Huzhou Academy of Agricultural Sciences, Huzhou 313000, China.
Animal. 2024 Sep;18(9):101282. doi: 10.1016/j.animal.2024.101282. Epub 2024 Aug 2.
BW is an important economic trait in sheep that influences growth and development. Currently, most studies have used a single approach to screen genes associated with BW traits in sheep. To address this limitation, we conducted a genome-wide association study (GWAS) covering four different BW periods: birth, weaning, 6 months, and 12 months. Five new candidate genes: MAP3K1, ANKRD55, ABCB1, MEF2C and TRNAW-CCA-87 were screened using a combination of GWAS and quantitative trait loci analysis in sheep. Additionally, five genes were subjected to Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. These genes were primarily enriched in pathways related to growth hormone and energy metabolism. The results demonstrated that the above genes potentially influenced the growth and development of sheep. The five new candidate genes are closely related to the BW trait in sheep, which will be valuable for understanding the genetic mechanisms underlying BW traits and for guiding sheep breeding.
体尺是影响绵羊生长发育的重要经济性状。目前，大多数研究都是采用单一的方法来筛选与绵羊体尺性状相关的基因。为了克服这一局限性，我们进行了一项全基因组关联研究（GWAS），涵盖了出生、断奶、6 月龄和 12 月龄四个不同的体尺时期。通过 GWAS 和绵羊数量性状位点分析相结合，筛选到了 5 个新的候选基因：MAP3K1、ANKRD55、ABCB1、MEF2C 和 TRNAW-CCA-87。此外，对 5 个基因进行了基因本体论和京都基因与基因组百科全书通路富集分析。这些基因主要富集在与生长激素和能量代谢相关的通路中。结果表明，上述基因可能影响绵羊的生长发育。这 5 个新的候选基因与绵羊的体尺性状密切相关，这对于了解体尺性状的遗传机制以及指导绵羊的选育具有重要意义。
