白细胞相关免疫球蛋白样受体 1（LAIR1）在子痫前期和胎儿生长受限中减少。
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is reduced with preeclampsia and small for gestational aged fetuses.
机构信息
Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, 3084, Victoria, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia.
Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Road, Heidelberg, 3084, Victoria, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia.
出版信息
Placenta. 2024 Oct;156:10-13. doi: 10.1016/j.placenta.2024.08.018. Epub 2024 Aug 29.
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is an inhibitory receptor expressed on immune cells. We evaluated LAIR1 in placentas from preeclamptic or small for gestational age (SGA) pregnancies, and placental explant model (1 % O, IL6 and TNFα, or control). LAIR1 mRNA was reduced in placentas from preeclamptic (p < 0.0001, n = 78) and SGA (p < 0.0001, n = 32) pregnancies. LAIR1 protein expression was reduced in placentas from preeclampsia (p < 0.0001, n = 43) and SGA (p = 0.009, n = 10) pregnancies. Hypoxia (1 % O) reduced LAIR1 mRNA expression in placental explants (p = 0.008). These findings suggest hypoxia modulates LAIR1 expression in the placenta.
白细胞相关免疫球蛋白样受体 1（LAIR1）是一种表达在免疫细胞上的抑制性受体。我们评估了子痫前期或胎儿生长受限（SGA）孕妇胎盘以及胎盘离体模型（1%O2、IL6 和 TNFα，或对照）中 LAIR1 的表达。子痫前期（p<0.0001，n=78）和 SGA（p<0.0001，n=32）孕妇胎盘中的 LAIR1mRNA 表达降低。子痫前期（p<0.0001，n=43）和 SGA（p=0.009，n=10）孕妇胎盘中的 LAIR1 蛋白表达降低。缺氧（1%O2）降低胎盘离体模型中 LAIR1mRNA 的表达（p=0.008）。这些发现表明缺氧调节胎盘内 LAIR1 的表达。
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