Kaya Sercan, Yalçın Tuba
Vocational Higher School of Healthcare Studies, Batman University, Batman, Turkey,.
J Trace Elem Med Biol. 2024 Dec;86:127510. doi: 10.1016/j.jtemb.2024.127510. Epub 2024 Aug 26.
Cadmium (Cd) is an environmental pollutant heavy metal with nephrotoxic effect. One of the primary constituents of essential oils is Linalool (Lin), a monoterpene having a variety of pharmacological properties including antimicrobial, anti-inflammatory, and antioxidant effects. The purpose of this study was to ascertain how Lin affected endoplasmic reticulum stress (ERS) and pro-inflammatory mediators in Cd-induced nephrotoxicity. In the experiment, 28 male rats were randomly divided into four equal groups as control (no application), Cd (Cd at a dose of 3 mg/kg for the first 7 days), Cd+Lin (Cd at a dose of 3 mg/kg for the first 7 days and 100 mg/kg/day Lin) and Lin (100 mg/kg/day Lin) (n=7). The experiment was completed on the 15th day after all treatments were performed. Blood serum and kidney tissue samples were used for analyses. Cd-induced histopathological changes, inflammation, oxidative stress, and apoptosis were determined to increase in kidney tissue. However, it was observed that Cd-induced adverse effects in kidney tissue were mainly eliminated by Lin treatment. In conclusion, Lin demonstrated anti-inflammatory, anti-oxidant and anti-apoptotic effects in Cd-induced nephrotoxicity. Therefore, we believe that Lin may represent a high potential therapeutic strategy against renal tissue damage.
镉（Cd）是一种具有肾毒性作用的环境污染物重金属。芳樟醇（Lin）是香精油的主要成分之一，它是一种单萜烯，具有多种药理特性，包括抗菌、抗炎和抗氧化作用。本研究的目的是确定Lin如何影响镉诱导的肾毒性中的内质网应激（ERS）和促炎介质。在实验中，28只雄性大鼠被随机分为四组，每组7只，分别为对照组（未给药）、Cd组（前7天给予3mg/kg剂量的Cd）、Cd+Lin组（前7天给予3mg/kg剂量的Cd，随后每天给予100mg/kg的Lin）和Lin组（每天给予100mg/kg的Lin）。所有处理完成后第15天结束实验。采集血清和肾脏组织样本进行分析。结果显示，镉诱导的肾脏组织病理变化、炎症、氧化应激和细胞凋亡均增加。然而，观察发现，Lin处理主要消除了镉对肾脏组织的不良影响。总之，Lin在镉诱导的肾毒性中表现出抗炎、抗氧化和抗凋亡作用。因此，我们认为Lin可能是一种治疗肾组织损伤的极具潜力的策略。
