Hyman P E, Garvey T Q, Harada T
J Pediatr Gastroenterol Nutr. 1985 Apr;4(2):316-9. doi: 10.1097/00005176-198504000-00029.
We studied the effect of ranitidine given in graded bolus intravenous doses on gastric acid hypersecretion in an unfed 3-month-old male with short bowel syndrome. We measured gastric volume and H+ serially for 12 h following each bolus and correlated inhibition of H+ secretion with plasma ranitidine concentration. In the first 4 h post drug, doses of 0.3, 1.0, 2.0, and 4.0 mg/kg resulted in 78, 93, 97, and 98% inhibition, respectively. The cumulative 12-h effect of the drug was to inhibit H+ secretion 67, 63, 72, and 87%. The IC50 for H+ secretion was between 50 and 100 ng/ml, and the IC90 between 130 and 150 ng/ml. Volume of gastric secretions was reduced by approximately 50% by all ranitidine doses. Because gastric acid hypersecretion interferes with nutrient absorption, the infant was treated with ranitidine during a 5-week trial of enteral feeding. A decrease in the antisecretory effect of ranitidine apparent at the end of the treatment period temporally related to an increase in oxyntic mucosal function. No adverse drug effects were observed during treatment.
我们研究了静脉推注不同剂量雷尼替丁对一名3个月大未进食的短肠综合征男性胃酸分泌过多的影响。在每次推注后连续12小时测量胃容量和氢离子，并将氢离子分泌的抑制与血浆雷尼替丁浓度相关联。在给药后的前4小时，0.3、1.0、2.0和4.0mg/kg的剂量分别导致78%、93%、97%和98%的抑制。该药物12小时的累积效应是抑制氢离子分泌67%、63%、72%和87%。氢离子分泌的半数抑制浓度（IC50）在50至100ng/ml之间，90%抑制浓度（IC90）在130至150ng/ml之间。所有雷尼替丁剂量均使胃分泌量减少约50%。由于胃酸分泌过多会干扰营养吸收，该婴儿在为期5周的肠内喂养试验期间接受了雷尼替丁治疗。在治疗期结束时，雷尼替丁的抗分泌作用下降，这在时间上与泌酸黏膜功能的增加有关。治疗期间未观察到药物不良反应。
