Levine N, Gerritsen M E, Carbonaro C, Tarlin N
J Reprod Fertil. 1985 Mar;73(2):539-45. doi: 10.1530/jrf.0.0730539.
Arachidonic acid stimulated an increase in transmural electrical potential difference (p.d.) in guinea-pig seminal vesicle tissue in vitro. Pretreatment with indomethacin abolished this response. Indomethacin pretreatment did not prevent the p.d. from increasing in response to theophylline. Changes in p.d. in response to arachidonic acid were greatly attenuated, and the response to theophylline was abolished in seminal vesicle tissue taken from castrated guinea-pigs. Seminal vesicles, aorta and ileum taken from castrated guinea-pigs synthesized and released more prostaglandins than did those from control animals. It is concluded that the effects of arachidonic acid on p.d. are mediated by its metabolism to prostaglandins; the inability of seminal vesicles from castrated animals to respond to arachidonic acid is not a result of a decrease in prostaglandin production, but is more likely a result of other degenerative changes attendant upon castration; and androgens appear to have some regulatory function on prostaglandin synthesis in a variety of tissues.
花生四烯酸可刺激豚鼠精囊组织的跨壁电势差（p.d.）升高。用吲哚美辛预处理可消除此反应。吲哚美辛预处理并未阻止因茶碱而导致的电势差升高。在去势豚鼠的精囊组织中，花生四烯酸引起的电势差变化显著减弱，对茶碱的反应则消失。与对照动物相比，去势豚鼠的精囊、主动脉和回肠合成并释放的前列腺素更多。得出的结论是，花生四烯酸对电势差的影响是通过其代谢为前列腺素介导的；去势动物的精囊对花生四烯酸无反应并非前列腺素生成减少所致，而更可能是去势伴随的其他退行性变化的结果；雄激素似乎对多种组织中的前列腺素合成具有某种调节功能。
