Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark; Integrative Neuroscience, Aalborg University, Hobrovej 18-22, Aalborg C 9000, Denmark.
Mech-Sense, Aalborg University Hospital, Aalborg, Denmark.
Prim Care Diabetes. 2024 Dec;18(6):606-611. doi: 10.1016/j.pcd.2024.08.006. Epub 2024 Aug 30.
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes, yet varying estimates of its prevalence exist. The present study aimed to estimate a questionnaire-centered prevalence of painful and painless DPN in the Northern Danish Region, examine its geographical distribution within the region, and investigate associations between DPN and potential risk factors.
A questionnaire-based survey was sent to all persons living with diabetes in the Northern Danish Region using electronic mail. Persons with diabetes were identified using The National Health Insurance Service Registry. The survey included information on demographics, socioeconomics, municipality, diabetes type, duration, and treatment, as well as the validated questionnaires Michigan Neuropathy Screening Instrument-questionnaire (MNSIq) and the Douleur Neuropathique en 4 Questions (DN4)-interview. Possible DPN was defined as an MNSIq-score ≥ 4, while possible painful DPN was defined as pain in both feet and a DN4-interview score ≥ 3.
A total of 23,206 eligible people were identified as having diabetes and approximately 33 % answered all questionnaires. The prevalence of possible DPN was 23.3 % (95 % CI: 22.4-24.3 %), while the prevalence of possible painful DPN was 18.0 % (17.1-18.8 %). The prevalence of possible DPN ranged from 22.1 % to 35.0 % between municipalities, while the prevalence of possible painful DPN ranged from 15.6 % to 20.0 %. High body-mass index, long diabetes duration, insulin use, glucagon-like-peptide-1-analogue use, and low income were associated with increased risk of DPN.
The high prevalence of possible painless and painful DPN emphasizes the need for better prevention and careful screening even in high-income countries.
糖尿病周围神经病变（DPN）是糖尿病的一种常见并发症，但对其患病率的估计存在差异。本研究旨在估计丹麦北部地区以问卷为中心的痛性和无痛性 DPN 患病率，研究其在该地区的地理分布，并调查 DPN 与潜在危险因素之间的关系。
使用电子邮件向丹麦北部地区所有患有糖尿病的人发送了一份基于问卷的调查。使用国家健康保险服务登记册确定患有糖尿病的人。该调查包括人口统计学、社会经济学、市、糖尿病类型、病程和治疗，以及经过验证的密歇根州周围神经病变筛查工具问卷（MNSIq）和 4 个问题的神经性疼痛问卷（DN4）访谈。可能的 DPN 定义为 MNSIq 评分≥4，而可能的痛性 DPN 定义为双脚疼痛和 DN4 访谈评分≥3。
共确定了 23206 名符合条件的糖尿病患者，约有 33%的人回答了所有问卷。可能的 DPN 患病率为 23.3%（95%CI：22.4-24.3%），而可能的痛性 DPN 患病率为 18.0%（17.1-18.8%）。各市政当局之间可能的 DPN 患病率从 22.1%到 35.0%不等，而可能的痛性 DPN 患病率从 15.6%到 20.0%不等。高体重指数、较长的糖尿病病程、胰岛素使用、胰高血糖素样肽-1 类似物使用和低收入与 DPN 风险增加相关。
无痛性和痛性 DPN 的高患病率强调了即使在高收入国家也需要更好的预防和仔细筛查。
