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食管癌中的外泌体:癌症进展、诊断、预后和治疗中极具潜力的纳米载体。

Exosomes in esophageal cancer: Promising nanocarriers in cancer progression, diagnosis, prognosis, and therapy.

机构信息

Department of Thoracic Surgery, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.

出版信息

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024 Sep-Oct;16(5):e1989. doi: 10.1002/wnan.1989.

Abstract

Esophageal cancer (EC) is one of the most fatal cancers all over the world. Sensitive detection modalities for early-stage EC and efficient treatment methods are urgently needed for the improvement of the prognosis of EC. Exosomes are small vesicles for intercellular communication, mediating many biological responses including cancer progression, which are not only promising biomarkers for diagnosis and prognosis but also therapeutic tools for EC. This review provides an overview of the relationships between exosomes and EC progression, as well as the application of exosomes in the diagnosis, prognosis, and treatment of EC. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

摘要

食管癌(EC)是全球最致命的癌症之一。为了改善 EC 的预后,迫切需要用于早期 EC 的敏感检测方式和有效的治疗方法。外泌体是细胞间通讯的小囊泡,介导包括癌症进展在内的许多生物学反应,它们不仅是用于诊断和预后的很有前途的生物标志物,也是 EC 的治疗工具。这篇综述提供了外泌体与 EC 进展之间关系的概述,以及外泌体在 EC 的诊断、预后和治疗中的应用。本文属于以下分类:治疗方法和药物发现 > 肿瘤疾病的纳米医学。

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