中国北京一家三甲医院不同孕期孕妇甲状腺功能与尿碘/肌酐比值的相关性。
The correlation between the thyroid function and urinary iodine/creatinine ratio of pregnant women attending a tertiary hospital in Beijing, China, during different trimesters.
机构信息
Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital Medical University, No. 95 of Yong an Road, Xicheng District, Beijing, 100050, China.
出版信息
BMC Endocr Disord. 2024 Sep 2;24(1):171. doi: 10.1186/s12902-024-01704-3.
OBJECTIVE
This study investigated the correlation between thyroid function and urinary iodine/creatinine ratio (UI/Cr) in pregnant women during different trimesters and explored potential influencing factors.
METHODS
In this cross-sectional study, serum levels of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), and UI/Cr were measured in 450 pregnant women. Correlations were analyzed using Pearson's correlation coefficient and multiple linear regression. Subgroup analyses were performed based on age, body mass index (BMI), parity, gestational age, education, occupation, and family history of thyroid disorders.
RESULTS
UI/Cr was positively correlated with FT4 levels in the first and second trimesters, particularly in women with older age, higher BMI, multiparity, higher education, and employment. No significant correlations were found between UI/Cr and TSH or FT3 levels.
CONCLUSION
UI/Cr is positively correlated with FT4 levels in early pregnancy, especially in women with certain risk factors. Regular monitoring of iodine status and thyroid function is recommended for pregnant women to ensure optimal maternal and fetal health.
目的
本研究旨在探讨不同孕期孕妇甲状腺功能与尿碘/肌酐比值（UI/Cr）的相关性，并探讨潜在的影响因素。
方法
本横断面研究共纳入 450 名孕妇，检测其血清促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）和 UI/Cr 水平。采用 Pearson 相关系数和多元线性回归分析相关性。根据年龄、体重指数（BMI）、产次、妊娠周数、受教育程度、职业和甲状腺疾病家族史进行亚组分析。
结果
UI/Cr 与第一和第二孕期的 FT4 水平呈正相关，特别是在年龄较大、BMI 较高、多产、受教育程度较高和有职业的女性中。UI/Cr 与 TSH 或 FT3 水平无显著相关性。
结论
UI/Cr 与早孕期 FT4 水平呈正相关，尤其是在具有某些危险因素的孕妇中。建议对孕妇进行碘状态和甲状腺功能的定期监测，以确保母婴健康。
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