Endocrine Research Center (Firouzgar), Institute of Endocrinology and Metabolism (Hemmat Campus), Tehran University of Medical Sciences, Tehran, Iran.
Gynecol Endocrinol. 2013 Jun;29(6):596-9. doi: 10.3109/09513590.2013.788640.
Significant changes in thyroid function occur during pregnancy which can complicate the interpretation of thyroid function tests. Therefore, normative gestational related reference ranges for thyroid hormones tests are required. The aim of this study was to determine the reference ranges for free triiodothyronine (FT3), free thyroxin (FT4) and thyroid stimulating hormone (TSH) in Iranian pregnant women.
This study was a cross-sectional observational study conducted in the Obstetrics and Gynecology department, Akbarabadi University Hospital. A single blood sample from 584 pregnant women was analyzed for thyroid function. Serum levels of TSH, FT4, FT3, total T4 (TT4), T3 resin uptake (T3RU) and anti-thyroid peroxidase antibody (TPO Ab) were measured. Urinary iodine was determined in some cases. Reference intervals based on 2.5th and 97.5th percentiles were calculated.
The composition of reference population comprising 584 women included 162 in first trimester and 422 in the third trimester. The 2.5th and 97.5th percentiles values were used to determine the reference ranges for FT3, FT4, TT4, T3RU and TSH. These values were T3 1.4 and 2.9 pmol/L, FT4 7.1 and 18 pmol/L, TT4 7.2 and 13.5 µg/dL and TSH 0.5 and 3.9 µg/L, respectively. The level of urinary iodine in 80.5% of the subjects was less than normal.
Serum levels of thyroid hormones are different in Iranian population that could be due to racial differences or differences in iodine intake.
怀孕期间甲状腺功能会发生显著变化，这可能会使甲状腺功能检测结果的解读变得复杂。因此，需要有针对妊娠期的正常参考值范围。本研究旨在确定伊朗孕妇游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）和促甲状腺激素（TSH）的参考范围。
这是一项在阿克巴巴迪大学医院妇产科进行的横断面观察性研究。对 584 名孕妇的单一血样进行了甲状腺功能分析。检测了血清 TSH、FT4、FT3、总 T4（TT4）、T3 树脂摄取（T3RU）和抗甲状腺过氧化物酶抗体（TPO Ab）水平。在某些情况下测定了尿碘。根据第 2.5 百分位数和第 97.5 百分位数计算参考区间。
参考人群由 584 名女性组成，其中 162 名处于孕早期，422 名处于孕晚期。第 2.5 百分位数和第 97.5 百分位数用于确定 FT3、FT4、TT4、T3RU 和 TSH 的参考范围。这些值分别为 T3 1.4 和 2.9 pmol/L、FT4 7.1 和 18 pmol/L、TT4 7.2 和 13.5 µg/dL 以及 TSH 0.5 和 3.9 µg/L。80.5%的研究对象尿碘水平低于正常值。
伊朗人群的甲状腺激素水平不同，这可能是由于种族差异或碘摄入差异所致。
