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下肢快速生长的平滑肌瘤酷似大隐神经鞘瘤:一例罕见病例报告。

Rapidly Growing Leiomyoma Mimicking Schwannoma of the Saphenous Nerve in the Lower Extremity: An Unusual Case Report.

机构信息

Department of Neurosurgery, University of Health Sciences, Kayseri City Hospital, Kayseri, Turkey.

Department of Pathology, University of Health Sciences, Kayseri City Hospital, Kayseri, Turkey.

出版信息

J Musculoskelet Neuronal Interact. 2024 Sep 1;24(3):325-329.

PMID:39219331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11367172/
Abstract

Leiomyomas and schwannomas are both types of rare benign soft tissue tumours. Leiomyomas are more commonly found in the lower limbs than in the upper extremities, while schwannomas are rare peripheral nerve sheath tumours that can occur in different anatomical regions. However, they rarely occur in the saphenous nerve. This case study presents a 41-year-old female patient with a solitary mass lesion located deep in the soft tissue of the anteromedial lower extremity. The physical examination revealed a palpable, elastic-hard, mobile and non-tender mass. Magnetic resonance imaging (MRI) showed an oval-shaped subcutaneous mass on contrast-enhanced T1-weighted sections. The initial MRI images suggested a schwannoma, but the tumour was later confirmed to be a leiomyoma after total enucleation. An immunohistochemical study was performed for differential diagnosis. Solitary mass lesions in the lower extremities can be mistaken for various types of tumours and misdiagnosed and require histopathological examination and good radiological imaging for differential diagnosis. Complete surgical excision is usually a safe and effective treatment for leiomyomas.

摘要

平滑肌瘤和神经鞘瘤均为罕见的良性软组织肿瘤。平滑肌瘤较常见于下肢,而上肢较少见,而神经鞘瘤则是一种罕见的周围神经鞘肿瘤,可发生于不同的解剖部位。然而,它们很少发生在隐神经上。本病例研究报告了一位 41 岁女性患者,其前内侧下肢深部软组织中存在单发肿块病变。体格检查发现可触及、弹性硬、可移动且无触痛的肿块。磁共振成像(MRI)显示增强 T1 加权切片上呈椭圆形皮下肿块。初始 MRI 图像提示为神经鞘瘤,但肿瘤在完全剜除后被证实为平滑肌瘤。进行了免疫组织化学研究以进行鉴别诊断。下肢单发肿块病变可能被误诊为各种类型的肿瘤,需要进行组织病理学检查和良好的影像学检查以进行鉴别诊断。完整的手术切除通常是治疗平滑肌瘤的安全有效方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6eb/11367172/00f18e57ccf9/JMNI-24-325-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6eb/11367172/b77fd1fc10a4/JMNI-24-325-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6eb/11367172/00f18e57ccf9/JMNI-24-325-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6eb/11367172/b77fd1fc10a4/JMNI-24-325-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6eb/11367172/00f18e57ccf9/JMNI-24-325-g002.jpg

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本文引用的文献

1
Sciatic nerve schwannoma complicated by nerve bundle membrane effusion: Two case reports and a literature review.坐骨神经鞘瘤合并神经束膜积液:两例报告及文献复习
Front Oncol. 2022 Sep 14;12:915982. doi: 10.3389/fonc.2022.915982. eCollection 2022.
2
Diagnostic Pathology of Tumors of Peripheral Nerve.周围神经肿瘤的诊断病理学。
Neurosurgery. 2021 Feb 16;88(3):443-456. doi: 10.1093/neuros/nyab021.
3
Massive pelvic recurrence of uterine leiomyomatosis with intracaval-intracardiac extension: video case report and literature review.
子宫平滑肌瘤病伴腔静脉-心内扩展的大量盆腔复发:视频病例报告及文献综述
BMC Surg. 2017 Nov 29;17(1):118. doi: 10.1186/s12893-017-0306-y.
4
Clinical Neuropathology image 1-2017: incidental schwannoma of the posterior root.临床神经病理学图像1 - 2017:后根偶然发现的神经鞘瘤。
Clin Neuropathol. 2017 Jan;36 (2017)(1):3-4. doi: 10.5414/NP301010.
5
Deep Soft Tissue Leiomyoma of Forearm: A Case Report and Review of Literature.前臂深部软组织平滑肌瘤:一例报告并文献复习
J Clin Diagn Res. 2016 Jun;10(6):RD03-5. doi: 10.7860/JCDR/2016/19059.8055. Epub 2016 Jun 1.
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Clinical and Sonographic Evaluation of a Lower Extremity Angioleiomyoma in a 52-Year-Old Woman.一名52岁女性下肢血管平滑肌瘤的临床及超声评估
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Unusual presentation of uterine leiomyoma.子宫平滑肌瘤的不典型表现。
BMJ Case Rep. 2015 Apr 9;2015:bcr2014208995. doi: 10.1136/bcr-2014-208995.
8
Solitary schwannoma of the sural nerve: An unusual clinical presentation.腓肠神经孤立性神经鞘瘤:一种不寻常的临床表现。
Exp Ther Med. 2014 Jan;7(1):90-92. doi: 10.3892/etm.2013.1395. Epub 2013 Nov 8.
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