Robin M, Forler C, Palfreyman M G
Pharmacol Biochem Behav. 1985 Apr;22(4):547-51. doi: 10.1016/0091-3057(85)90273-4.
We hypothesised that it would be possible to prevent the development of post-synaptic dopamine receptor supersensitivity to 6-hydroxydopamine lesions of the nigro-striatal tract in rats if they were constantly infused with the dopamine agonist apomorphine. Using osmotic minipumps to infuse apomorphine for 15 days in unilaterally lesioned rats, it was possible to delay the development of supersensitivity of the lesioned side for 9 days but not to prevent its eventual appearance. At the same time, evidence for the development of subsensitivity of presynaptic dopamine receptors of the intact side following chronic infusion of apomorphine was inferred from the production of rotations directed towards the lesioned side.
我们推测，如果持续给大鼠输注多巴胺激动剂阿扑吗啡，就有可能预防黑质纹状体束6-羟基多巴胺损伤后突触后多巴胺受体超敏反应的发生。在单侧损伤的大鼠中，使用渗透微型泵输注阿扑吗啡15天，有可能将损伤侧超敏反应的发生延迟9天，但无法阻止其最终出现。同时，从向损伤侧旋转的产生推断，慢性输注阿扑吗啡后完整侧突触前多巴胺受体出现亚敏反应。
