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纳曲酮在异食癖和其他强迫行为中的非标签使用：两例报告

Off-Label Use of Naltrexone in Pica and Other Compulsive Behaviors: A Report of Two Cases.

作者信息

Khan Samira, Vij Kunal, Lopez Emili

机构信息

Behavioral Health, West Virginia University (WVU) Berkeley Medical Center, Martinsburg, USA.

School of Osteopathic Medicine, West Virginia School of Osteopathic Medicine, Lewisburg, USA.

出版信息

Cureus. 2024 Jul 31;16(7):e65845. doi: 10.7759/cureus.65845. eCollection 2024 Jul.

DOI:10.7759/cureus.65845
PMID:39219950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11363882/
Abstract

Pica is known to the medical community as an eating disorder in which individuals may ingest non-food items due to a nutritional deficiency and cause unintentional physical harm to themselves. This article discusses the cases of children with pica in addition to other comorbidities such as trichotillomania, depression, autism, and anxiety. Both patients were trialed on typical first-line treatments to address pica symptoms, including antidepressants, psychotherapy, and neurology consults, which were ineffective in treating pica symptoms. The introduction of naltrexone resulted in significant improvements, including decreased pica symptoms and improvements in depression, anxiety, and overall behaviors. These effects of naltrexone were further bolstered by the effects that occurred when both patients discontinued naltrexone for some time.

摘要

异食癖在医学界被认为是一种饮食失调症，患者可能由于营养缺乏而摄入非食物物品，并对自身造成意外伤害。本文除了讨论患有异食癖的儿童病例外，还探讨了其他共病，如拔毛癖、抑郁症、自闭症和焦虑症。两名患者都接受了针对异食癖症状的典型一线治疗，包括抗抑郁药、心理治疗和神经科会诊，但这些治疗对治疗异食癖症状均无效。纳曲酮的引入带来了显著改善，包括异食癖症状减轻以及抑郁、焦虑和整体行为的改善。当两名患者都停用纳曲酮一段时间后出现的效果，进一步增强了纳曲酮的这些作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6b/11363882/c3d531d9c7c3/cureus-0016-00000065845-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6b/11363882/850c936b8908/cureus-0016-00000065845-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6b/11363882/9e8fabb1dc0d/cureus-0016-00000065845-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6b/11363882/8400c11ebb4b/cureus-0016-00000065845-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6b/11363882/ee84fcbbd017/cureus-0016-00000065845-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6b/11363882/1125e673c369/cureus-0016-00000065845-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6b/11363882/587af7da680a/cureus-0016-00000065845-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6b/11363882/c3d531d9c7c3/cureus-0016-00000065845-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6b/11363882/850c936b8908/cureus-0016-00000065845-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6b/11363882/9e8fabb1dc0d/cureus-0016-00000065845-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6b/11363882/8400c11ebb4b/cureus-0016-00000065845-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6b/11363882/ee84fcbbd017/cureus-0016-00000065845-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6b/11363882/1125e673c369/cureus-0016-00000065845-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6b/11363882/587af7da680a/cureus-0016-00000065845-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6b/11363882/c3d531d9c7c3/cureus-0016-00000065845-i07.jpg

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The Neurology and Psychopathology of Pica.异食癖的神经学与精神病理学
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Developmental Considerations for the Use of Naltrexone in Children and Adolescents.纳曲酮在儿童和青少年中使用的发育方面考量
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