Fu Xiaoming, Zeng Fuhai, Li Linling, Liu Guoquan, Zhong Qing, Chen Shouwan
Department of Burn and Plastic Surgery, The People's Hospital of Jianyang City, Jianyang, Sichuan, People's Republic of China.
Department of Plastic and Maxillofacial Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Clin Cosmet Investig Dermatol. 2024 Aug 28;17:1963-1972. doi: 10.2147/CCID.S472443. eCollection 2024.
The existing observational research on the relationship between physical activity (PA) and skin cancer (SC) is contentious, which points to the intricate nature of their association and underscores the imperative for more nuanced research to untangle the causal dynamics at play. The aim of this article is to delve deeper into this complex relationship, seeking to clarify whether PA serves as a protective factor against SC, or contributes to its risk.
We utilized data from the genome-wide association study (GWAS) of PA from GWAS Catalog (include self-reported moderate to vigorous PA (MVPA), self-reported vigorous PA (VPA), and accelerometer-based average-accelerated PA). The data of SC is from FinnGen. All of the participants are of European ancestry. We used two-sample Mendelian Randomization (TSMR) to analyze the causal relationship between PA and SC.The research was conducted using inverse variance weighted (IVW) method as the primary approach, and MR Egger regression as supplementary analytical method. To ensure the robustness of the results, Cochran's Q-test and MR pleiotropy residual sum and outlier (MR-PRESSO) global tests were used to measure sensitivity.
Our analysis indicated that average-accelerated PA was associated with an increased risk of SC (OR = 0.94, 95% CI 0.93-0.96, P < 0.001). While neither MVPA (OR = 0.99, 95% CI 0.67-1.47, P = 0.962) nor VPA (OR = 0.80, 95% CI 0.29-2.18, P = 0.656) shows causal relationship on risk of SC.
Our research suggests that PA is associated with a decrease in SC, provides a new perspective for future SC prevention. Our research findings bolster the hypothesis that increased levels of PA, characterized by average acceleration, are associated with a reduced risk of developing skin cancer. This has filled the gap of research on the causal relationship between PA and SC, and could pave the way for novel preventive strategies against skin cancer.
现有关于身体活动（PA）与皮肤癌（SC）之间关系的观察性研究存在争议，这表明它们之间关联的复杂性，并强调需要进行更细致入微的研究来理清其中的因果动态关系。本文旨在更深入地探究这种复杂关系，试图阐明PA是对SC起到保护作用，还是会增加其风险。
我们利用了来自GWAS Catalog中PA的全基因组关联研究（GWAS）数据（包括自我报告的中度至剧烈身体活动（MVPA）、自我报告的剧烈身体活动（VPA）以及基于加速度计的平均加速度身体活动）。SC的数据来自芬兰基因组计划。所有参与者均为欧洲血统。我们使用两样本孟德尔随机化（TSMR）来分析PA与SC之间的因果关系。研究以逆方差加权（IVW）方法作为主要方法，以MR Egger回归作为补充分析方法。为确保结果的稳健性，使用 Cochr an Q检验和MR多效性残差和异常值（MR-PRESSO）全局检验来测量敏感性。
我们的分析表明，平均加速度身体活动与SC风险增加相关（比值比=0.94，95%置信区间0.93 - 0.96，P<0.001）。而MVPA（比值比=0.99，95%置信区间0.67 - 1.47，P = 0.962）和VPA（比值比=0.80，95%置信区间0.29 - 2.18，P = 0.656）均未显示出与SC风险存在因果关系。
我们的研究表明PA与SC风险降低相关，为未来SC预防提供了新视角。我们的研究结果支持了以下假设，即以平均加速度为特征的PA水平升高与患皮肤癌风险降低相关。这填补了PA与SC因果关系研究的空白，并可能为预防皮肤癌的新策略铺平道路。
