Qadeer Abdul, Ishaq Muhammad Umer, Safi Adnan, Akbar Anum, Asif Sana, Komel Aqsa, Kunwar Digbijay, Bokhari Syed Mujtaba Azhar
Department of Cardiovascular Medicine, Shifa International Hospital, Islamabad, Pakistan.
Department of Medicine, Nishtar Medical University, Multan, Pakistan.
Ther Adv Reprod Health. 2024 Aug 31;18:26334941241271542. doi: 10.1177/26334941241271542. eCollection 2024 Jan-Dec.
Gestational diabetes mellitus (GDM) and thyroid disorders during pregnancy pose significant health concerns, impacting a substantial number of mothers globally. Globally, about 14% of pregnant women develop GDM, while thyroid disorders impact approximately 2%-3%. Both conditions contribute to adverse outcomes, including gestational hypertension, excessive fetal growth, and heightened perinatal morbidity. The central focus of this literature review is to examine the relationship between vitamin A, a crucial fat-soluble micronutrient in fetal development, and the occurrence of GDM and thyroid disorders during pregnancy. The primary research question investigates the association between vitamin A, GDM, and thyroid disorders, analyzing their combined impact on maternal, fetal, and neonatal outcomes. The review underscores the potential of vitamin A to modulate the risk and outcomes of GDM and thyroid disorders during gestation, emphasizing its role in GDM development and resolution and its influence on thyroid function in pregnancy.
妊娠期糖尿病（GDM）和孕期甲状腺疾病引发了重大的健康问题，对全球大量母亲产生影响。在全球范围内，约14%的孕妇会患妊娠期糖尿病，而甲状腺疾病影响约2%-3%的孕妇。这两种情况都会导致不良后果，包括妊娠期高血压、胎儿过度生长和围产期发病率升高。这篇文献综述的核心重点是研究维生素A（胎儿发育中一种关键的脂溶性微量营养素）与孕期妊娠期糖尿病和甲状腺疾病发生之间的关系。主要研究问题是调查维生素A、妊娠期糖尿病和甲状腺疾病之间的关联，分析它们对母亲、胎儿和新生儿结局的综合影响。该综述强调了维生素A在调节孕期妊娠期糖尿病和甲状腺疾病的风险及结局方面的潜力，强调了其在妊娠期糖尿病发生和缓解中的作用以及对孕期甲状腺功能的影响。
