一项使用磷脂酶A2抑制剂依地酸钙钠治疗人类急性胰腺炎的随机双盲研究。

A randomized double-blind study using CaNa2EDTA, a phospholipase A2 inhibitor, in the management of human acute pancreatitis.

作者信息

Tykkä H T, Vaittinen E J, Mahlberg K L, Railo J E, Pantzar P J, Sarna S, Tallberg T

出版信息

Scand J Gastroenterol. 1985 Jan;20(1):5-12. doi: 10.3109/00365528509089625.

PMID:3922048

Abstract

In a randomized double-blind study the effect of CaNa2EDTA, a phospholipase A2 inhibitor, was tested as a treatment for acute pancreatitis. CaNa2EDTA was infused intravenously during the first 2 days after admission to hospital, in addition to normal conservative treatment. CaNa2EDTA decreased the serum phospholipase A2 activity and appeared to promote recovery from the illness. To what extent the inhibition of serum phospholipase activity may prevent the progress of severe haemorrhagic pancreatitis or diminish mortality and morbidity in acute pancreatitis should be investigated in further studies.

摘要

在一项随机双盲研究中，对磷脂酶A2抑制剂依地酸钙钠（CaNa2EDTA）作为急性胰腺炎治疗方法的效果进行了测试。除常规保守治疗外，在入院后的头2天内静脉输注依地酸钙钠。依地酸钙钠降低了血清磷脂酶A2活性，似乎促进了疾病的康复。血清磷脂酶活性的抑制在多大程度上可以预防重症出血性胰腺炎的进展或降低急性胰腺炎的死亡率和发病率，应在进一步的研究中进行调查。