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Investigation of Host-Guest Inclusion Complex of Mephenesin with α-Cyclodextrin for Innovative Application in Biological System.

作者信息

Debnath Subhajit, Ghosh Biswajit, Mondal Modhusudan, Roy Niloy, Mallick Kangkan, Maji Joydeb, Sahana Sudip, Sinha Anuradha, Dey Sangita, Kumar Anoop, Roy Mahendra Nath

机构信息

Department of Chemistry, University of North Bengal, Darjeeling, West Bengal 734013, India.

Department of Botany, Siliguri College, Siliguri, Darjeeling, West Bengal 734001, India.

出版信息

ACS Omega. 2024 Aug 15;9(34):36066-36075. doi: 10.1021/acsomega.3c08185. eCollection 2024 Aug 27.

DOI:10.1021/acsomega.3c08185
PMID:39220532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11359629/
Abstract

The goal of this study was to use coevaporation to look into how polyether compounds like mephenesin (MEP) can be encapsulated into the host molecule α-cyclodextrin's nanohydrophobic cage. Fourier transform infrared spectroscopy (FT-IR) investigations, powder X-ray diffraction (PXRD), and H NMR were among the spectroscopic techniques used to describe the inclusion complex. Additionally, Job's plot has been utilized to illustrate how MEP is encapsulated with α-cyclodextrin (α-CD) at a 1:1 molar ratio. The thermal stability of MEP increased after encapsulation according to thermogravimetric analysis (TGA) and differential thermal analysis (DTA) experiments. Mephenesin fits into the cavity of α-cyclodextrin in a 1:1 ratio, as observed by molecular docking for the inclusion complex to find the most appropriate orientation. This observation is further supported by the Job plot. Furthermore, a comparison was carried out based on a cell viability study between the medication and its inclusion complex.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/a3c56b5929bd/ao3c08185_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/53f2f1d3955b/ao3c08185_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/54d589cba278/ao3c08185_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/7ff6f8b50cbf/ao3c08185_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/679fc96048ca/ao3c08185_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/c6c69abfdef9/ao3c08185_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/75ae29598a64/ao3c08185_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/23ba587a0ab0/ao3c08185_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/d1b039315cb6/ao3c08185_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/9514523079d9/ao3c08185_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/a3c56b5929bd/ao3c08185_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/53f2f1d3955b/ao3c08185_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/54d589cba278/ao3c08185_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/7ff6f8b50cbf/ao3c08185_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/679fc96048ca/ao3c08185_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/c6c69abfdef9/ao3c08185_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/75ae29598a64/ao3c08185_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/23ba587a0ab0/ao3c08185_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/d1b039315cb6/ao3c08185_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/9514523079d9/ao3c08185_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad5e/11359629/a3c56b5929bd/ao3c08185_0009.jpg

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引用本文的文献

[1]
Effect of Reaction Parameters on the Synthesis of Cyclodextrin-Based Nanostructured Polymers for Drug Delivery.

Polymers (Basel). 2025-3-7

本文引用的文献

[1]
Probing the Molecular Assembly of a Metabolizer Drug with β-Cyclodextrin and Its Binding with CT-DNA in Augmenting Antibacterial Activity and Photostability by Physicochemical and Computational Methodologies.

ACS Omega. 2022-7-19

[2]
Structure confirmation and thermal kinetics of the inclusion of -jasmone in β-cyclodextrin.

RSC Adv. 2019-8-21

[3]
Anti-Tumor Efficiency of Perillylalcohol/β-Cyclodextrin Inclusion Complexes in a Sarcoma S180-Induced Mice Model.

Pharmaceutics. 2021-2-10

[4]
Exploring the Inclusion Complex of a Drug (Umbelliferone) with α-Cyclodextrin Optimized by Molecular Docking and Increasing Bioavailability with Minimizing the Doses in Human Body.

ACS Omega. 2020-11-13

[5]
Cyclodextrin-based delivery systems for chemotherapeutic anticancer drugs: A review.

Carbohydr Polym. 2019-12-30

[6]
Troxerutin subdues hepatic tumorigenesis via disrupting the MDM2-p53 interaction.

Food Funct. 2018-10-17

[7]
Construction of 6-thioguanine and 6-mercaptopurine carriers based on βcyclodextrins and gold nanoparticles.

Carbohydr Polym. 2017-8-25

[8]
Experimental, molecular docking investigations and bioavailability study on the inclusion complexes of finasteride and cyclodextrins.

Drug Des Devel Ther. 2017-6-7

[9]
Study to explore the mechanism to form inclusion complexes of β-cyclodextrin with vitamin molecules.

Sci Rep. 2016-10-20

[10]
Probing inclusion complexes of cyclodextrins with amino acids by physicochemical approach.

Carbohydr Polym. 2016-5-28

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