Salgın Sema, Eke Hasan Hüseyin, Soyer Nagihan, Salgın Uğur
Department of Chemical Engineering, Faculty of Engineering, Sivas Cumhuriyet University, 58140 Sivas, Turkey.
Farma-Tek Pharmaceutical Industry and Trade Inc., 39100 Kırklareli, Turkey.
Polymers (Basel). 2025 Mar 7;17(6):709. doi: 10.3390/polym17060709.
In this study, cyclodextrin-based nanostructures (CDNSs) were synthesized through the cross-linking of cyclodextrin (CD) with epichlorohydrin (ECH) as a cross-linker. Two types of CDNSs, α-CDNS and β-CDNS, were prepared to systematically investigate the influence of reaction parameters-such as the solubilization time of α-CD and β-CD, the molar ratio of ECH to CD, and NaOH concentration-on the physicochemical properties of the final product. Naproxen (NAP), a poorly water-soluble drug, was selected as a model compound to assess the drug-loading capacity of the synthesized CDNSs. The effect of each reaction parameter on NAP integration into the CDNSs was examined at varying weight ratios. The optimal reaction conditions were determined to be a solubilization time of 6 h, an ECH/CD molar ratio of 8/1, and an NaOH concentration of 33%. Under these conditions, the NAP loading efficiency of α-CDNSs was calculated as 67.12%. Comparative analysis revealed that α-CDNSs outperformed β-CDNSs in terms of drug-loading capacity. Additionally, the synthesized CDNSs and NAP-loaded CDNSs were characterized using FTIR, DSC, XRD, SEM, and Zetasizer analyses, while the NAP concentration was determined by HPLC.
在本研究中，基于环糊精的纳米结构（CDNSs）通过环糊精（CD）与作为交联剂的环氧氯丙烷（ECH）交联合成。制备了两种类型的CDNSs，即α - CDNS和β - CDNS，以系统研究反应参数（如α - CD和β - CD的溶解时间、ECH与CD的摩尔比以及NaOH浓度）对最终产物物理化学性质的影响。选择难溶性药物萘普生（NAP）作为模型化合物，以评估合成的CDNSs的载药能力。在不同的重量比下，研究了每个反应参数对NAP整合到CDNSs中的影响。确定最佳反应条件为溶解时间6小时、ECH/CD摩尔比8/1以及NaOH浓度33%。在这些条件下，α - CDNSs的NAP负载效率计算为67.12%。对比分析表明，α - CDNSs在载药能力方面优于β - CDNSs。此外，使用傅里叶变换红外光谱（FTIR）、差示扫描量热法（DSC）、X射线衍射（XRD）、扫描电子显微镜（SEM）和Zetasizer分析对合成的CDNSs和负载NAP的CDNSs进行了表征，同时通过高效液相色谱法（HPLC）测定了NAP浓度。
