Chen Lei, Tong Cong, Zhao Xiangan, Xu Chunfang
Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.
Department of Gastroenterology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China.
Open Life Sci. 2024 Aug 23;19(1):20220852. doi: 10.1515/biol-2022-0852. eCollection 2024.
The aim of the present study is to explore the potential prediction value of neutrophil-to-lymphocyte ratio (NLR) or peripheral blood platelet-to-lymphocyte ratio (PLR) for rebleeding in patients with esophagogastric variceal bleeding (EVB). We have enrolled 80 rebleeding patients with EVB and 113 EVB patients without rebleeding in the present study. The lymphocyte, platelet counts, the PLR, and the NLR of the candidates were calculated, and receiver-operating characteristic curve was drawn to examine whether NLR or PLR is a sensitive biomarker for distinguishing rebleeding patients from the EVB patients. We observed that NLR and PLR were all significantly increased in rebleeding patients with EVB compared with the non-rebleeding patients ( < 0.01); moreover, the area under the curve of NLR and PLR was 0.7037 (95% confidence interval [CI], 0.6281-0.7792) and 0.7468 (95% CI, 0.6793-0.8144), respectively, suggesting that NLR or PLR is a sensitive biomarker for distinguishing non-rebleeding patients from the rebleeding patients. We reported that NLR and PLR were significantly increased in the peripheral blood of patient with esophagogastric variceal rebleeding, suggesting that NLR and PLR may be potential early diagnostic and prognostic markers for the rebleeding among patients with EVB.
本研究旨在探讨中性粒细胞与淋巴细胞比值（NLR）或外周血血小板与淋巴细胞比值（PLR）对食管胃静脉曲张破裂出血（EVB）患者再出血的潜在预测价值。在本研究中，我们纳入了80例EVB再出血患者和113例未发生再出血的EVB患者。计算入选者的淋巴细胞、血小板计数、PLR和NLR，并绘制受试者工作特征曲线，以检验NLR或PLR是否是区分再出血患者和EVB患者的敏感生物标志物。我们观察到，与未再出血的患者相比，EVB再出血患者的NLR和PLR均显著升高（<0.01）；此外，NLR和PLR的曲线下面积分别为0.7037（95%置信区间[CI]，0.6281 - 0.7792）和0.7468（95%CI，0.6793 - 0.8144），这表明NLR或PLR是区分未再出血患者和再出血患者的敏感生物标志物。我们报道，食管胃静脉曲张再出血患者外周血中的NLR和PLR显著升高，这表明NLR和PLR可能是EVB患者再出血的潜在早期诊断和预后标志物。
