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肝移植受者术后吞咽困难的预测因素

Predictors for postoperative dysphagia in liver transplant recipients.

作者信息

Isdahl Marian, Katz Lily, Johnson Michaela, Leverson Glen, Al-Adra David, Thibeault Susan

机构信息

Department of Surgery, Division of Otolaryngology - Head and Neck Surgery, University of Wisconsin, Madison, WI, United States.

Department of Brain and Spine, University of Tennessee Medical Center, Knoxville, TN, United States.

出版信息

Front Transplant. 2024 Aug 16;3:1415141. doi: 10.3389/frtra.2024.1415141. eCollection 2024.

Abstract

INTRODUCTION

Liver transplant recipients are at a heightened risk for oropharyngeal dysphagia; identification of those who are at high risk for postoperative dysphagia could reduce hospital costs and length of stay. We sought to identify predictors of dysphagia, in a large cohort of patients who underwent liver transplantation.

METHODS

Electronic medical records were queried for patients undergoing liver transplantation, who underwent instrumental swallowing evaluations. Demographics, functional outcomes, and interventions were collected. Logistic regression analyses were performed to identify predictors of dysphagia.

RESULTS

Seven hundred and ninety-five patients met inclusionary criteria. Multivariate analyses found ethnic group ( = .0191), MELD Score ( < 0001), cold ischemia time ( = .0123), and length of intubation ( < .0001) to be predictors of post-operative development of dysphagia. Pre-transplant dialysis ( < .0001), dysphagia related to end stage liver disease ( < .0001), Karnofsky Performance Status Scale ( < .0001), wait time to transplant ( = 0.0173), surgery time ( = 0.0095), tracheostomy ( < 0.0001), and transfusion of intraoperative RBC ( < .0001), intraoperative platelets ( = 0.0018), intraoperative FFP ( = 0.0495), perioperative FFP ( = 0.0002), perioperative platelets ( = 0.0151) and perioperative RBC ( = 0.0002) were variables of significance associated with the development of postoperative dysphagia from univariate analysis.

CONCLUSIONS

Our results propose a set of predictors that should be considered when identifying post-operative critically ill patients at risk for dysphagia.

摘要

引言

肝移植受者发生口咽吞咽困难的风险较高;识别术后吞咽困难的高危患者可降低医院成本和住院时间。我们试图在一大群接受肝移植的患者中确定吞咽困难的预测因素。

方法

查询接受肝移植并进行仪器吞咽评估的患者的电子病历。收集人口统计学、功能结局和干预措施。进行逻辑回归分析以确定吞咽困难的预测因素。

结果

795名患者符合纳入标准。多变量分析发现种族(P = 0.0191)、终末期肝病模型(MELD)评分(P < 0.0001)、冷缺血时间(P = 0.0123)和插管时间(P < 0.0001)是术后吞咽困难发生的预测因素。移植前透析(P < 0.0001)、与终末期肝病相关的吞咽困难(P < 0.0001)、卡诺夫斯基功能状态量表(P < 0.0001)、等待移植时间(P = 0.0173)、手术时间(P = 0.0095)、气管切开术(P < 0.0001)以及术中红细胞输注(P < 0.0001)、术中血小板输注(P = 0.0018)、术中新鲜冰冻血浆输注(P = 0.0495)、围手术期新鲜冰冻血浆输注(P = 0.0002)围手术期血小板输注(P = 0.0151)和围手术期红细胞输注(P = 0.0002)是单变量分析中与术后吞咽困难发生相关的显著变量。

结论

我们的结果提出了一组预测因素,在识别有吞咽困难风险的术后重症患者时应予以考虑。

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Predictors for postoperative dysphagia in liver transplant recipients.肝移植受者术后吞咽困难的预测因素
Front Transplant. 2024 Aug 16;3:1415141. doi: 10.3389/frtra.2024.1415141. eCollection 2024.

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