Alphonsus Lotus, Zhang Qi, Jairath Vipul
Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University and London Health Sciences Centre, London, Ontario, Canada.
ACG Case Rep J. 2024 Aug 29;11(9):e01468. doi: 10.14309/crj.0000000000001468. eCollection 2024 Sep.
Epstein-Barr Virus-positive mucocutaneous ulcer (EBVMCU) is a rare and new category of mature B-cell neoplasms commonly linked to immunosuppression. It often has a benign course and regresses spontaneously after discontinuation or dose reduction of immunosuppressive agents. We report the case of a 48-year-old woman on long-term azathioprine therapy for rectosigmoid Crohn's disease. In contrast to the prevalent sites typically associated with EBVMCU, such as the oral mucosa and skin, this patient was found to have locations in the gastrointestinal tract and upper neck. These areas tested positive for histopathology consistent with EBVMCU and were excised due to bowel perforation and concern for malignancy.
爱泼斯坦-巴尔病毒阳性黏膜皮肤溃疡（EBVMCU）是一种罕见的新型成熟B细胞肿瘤，通常与免疫抑制有关。它通常病程良性，在停用免疫抑制剂或减少免疫抑制剂剂量后可自发消退。我们报告了一例48岁女性病例，该患者因直肠乙状结肠克罗恩病接受长期硫唑嘌呤治疗。与EBVMCU通常相关的常见部位（如口腔黏膜和皮肤）不同，该患者的病变位于胃肠道和上颈部。这些部位经组织病理学检查确诊为EBVMCU阳性，因肠穿孔及担心恶变而进行了切除。
