Guanín Cabrera Carlos Luis, Jaramillo Arturo P, Vallejo Maria P, Cueva Maria G, Grandes Xavier, Navarro Grijalva Mario, Hidalgo Guerrero Over J
General Practice, Universidad Católica de Santiago de Guayaquil, Guayaquil, ECU.
General Practice, Universidad Estatal de Guayaquil, Machala, ECU.
Cureus. 2024 Aug 1;16(8):e65972. doi: 10.7759/cureus.65972. eCollection 2024 Aug.
Alzheimer's disease (AD) remains a widespread cause of dementia globally, and its prevalence is increasing due to the aging population. Two key pathologies typically identify this neurodegenerative disease process: the accumulation of amyloid plaques and the formation of neurofibrillary tangles containing hyperphosphorylated tau. Diagnosis relies on the patient's clinical presentation meeting specific criteria, along with the use of fluid and imaging biomarkers. The current treatment focuses on addressing symptoms, with ongoing trials aiming to decrease the production and overall impact of brain pathology. Here, we explore various methods to minimize the risks of AD in patients and individuals at high risk of developing it. To address this, we carefully selected 10 articles that discuss various prevention methods used today to promote brain health, including diets that are believed to have neuroprotective properties. The study findings emphasize the importance of further strengthening the evidence and conducting larger randomized controlled trials to gain a better understanding of the potential benefits for individuals at high risk of developing AD, as well as those already diagnosed with it.
阿尔茨海默病(AD)仍然是全球痴呆症的一个普遍病因,并且由于人口老龄化,其患病率正在上升。两种关键的病理学特征通常可识别这种神经退行性疾病过程:淀粉样斑块的积累以及含有高度磷酸化tau的神经原纤维缠结的形成。诊断依赖于患者的临床表现符合特定标准,以及使用体液和影像学生物标志物。目前的治疗侧重于缓解症状,正在进行的试验旨在减少脑部病理的产生及其总体影响。在此,我们探讨各种方法以将AD患者以及有高发病风险个体的患病风险降至最低。为此,我们精心挑选了10篇文章,这些文章讨论了当今用于促进大脑健康的各种预防方法,包括据信具有神经保护特性的饮食。研究结果强调了进一步加强证据以及开展更大规模随机对照试验的重要性,以便更好地了解这些方法对有高AD发病风险的个体以及已确诊患者的潜在益处。