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布洛芬:无菌性脑膜炎背后的隐藏元凶。

Ibuprofen: The Hidden Culprit Behind Aseptic Meningitis.

作者信息

Kalfoutzou Areti, Petroulakis Pantelis, Tsiouri Eleni, Fafoutis Theodoros, Mylonakis Adam, Dimitrakoudi Maria, Mylonaki Maria, Piperis Christos, Mostratou Eleni

机构信息

Department of Oncology, 251 Air Force General Hospital, Athens, GRC.

Second Department of Internal Medicine, 251 Air Force General Hospital, Athens, GRC.

出版信息

Cureus. 2024 Aug 1;16(8):e65936. doi: 10.7759/cureus.65936. eCollection 2024 Aug.

DOI:10.7759/cureus.65936
PMID:39221408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11365196/
Abstract

Drug-induced aseptic meningitis represents a significant clinical entity characterized by an inflammatory response of the meninges triggered by specific pharmacological agents. This condition predominantly manifests as a delayed hypersensitivity reaction to a variety of drugs, most notably non-steroidal anti-inflammatory drugs, antibiotics, immune checkpoint inhibitors, and monoclonal antibodies. We report a case of aseptic meningitis in a 54-year-old male presenting with nausea and blurred vision two hours after taking ibuprofen. This case aims to highlight one underrecognized adverse event associated with one of the most commonly used over-the-counter medications worldwide.

摘要

药物性无菌性脑膜炎是一种重要的临床病症,其特征是特定药理剂引发的脑膜炎症反应。这种病症主要表现为对多种药物的迟发型超敏反应,最常见的是非甾体抗炎药、抗生素、免疫检查点抑制剂和单克隆抗体。我们报告一例54岁男性在服用布洛芬两小时后出现恶心和视力模糊的无菌性脑膜炎病例。该病例旨在突出一种与全球最常用的非处方药之一相关但未被充分认识的不良事件。

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Ibuprofen: The Hidden Culprit Behind Aseptic Meningitis.布洛芬:无菌性脑膜炎背后的隐藏元凶。
Cureus. 2024 Aug 1;16(8):e65936. doi: 10.7759/cureus.65936. eCollection 2024 Aug.
2
[Recurrent aseptic meningitis secondary to taking ibuprofen and ketorolac].服用布洛芬和酮咯酸继发复发性无菌性脑膜炎
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IBUPROFEN-INDUCED ASEPTIC MENINGITIS: A CASE REPORT.布洛芬诱发的无菌性脑膜炎:一例报告
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Recurrent ibuprofen-induced aseptic meningitis.复发性布洛芬诱发的无菌性脑膜炎。
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本文引用的文献

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Drug-induced aseptic meningitis to ibuprofen: The first case confirmed by positive patch test.布洛芬所致药物性无菌性脑膜炎:首例经阳性斑贴试验确诊的病例。
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Meningitis due to non-steroidal anti-inflammatory drugs: an often-overlooked complication of a widely used medication.非甾体抗炎药所致脑膜炎:一种广泛使用药物常被忽视的并发症。
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IBUPROFEN-INDUCED ASEPTIC MENINGITIS: A CASE REPORT.
布洛芬诱发的无菌性脑膜炎:一例报告
Rev Paul Pediatr. 2019 Jun 3;37(3):382-385. doi: 10.1590/1984-0462/;2019;37;3;00016. eCollection 2019.
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Recurrent case of ibuprofen-induced aseptic meningitis in mixed connective tissue disease.混合性结缔组织病中布洛芬诱发的无菌性脑膜炎复发病例。
BMJ Case Rep. 2013 Apr 30;2013:bcr2013009571. doi: 10.1136/bcr-2013-009571.
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Ibuprofen-induced aseptic meningoencephalitis confirmed by drug challenge.药物激发试验证实布洛芬致无菌性脑膜炎脑炎。
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