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肺毛霉病的致命病程:一例报告

The Fatal Course of Pulmonary Mucormycosis: A Case Report.

作者信息

Sindhu Arman, Jadhav Ulhas, Ghewade Babaji, Bhanushali Jay, Sarkar Souvik, Yadav Pallavi

机构信息

Department of Respiratory Medicine, Jawaharlal Nehru Medical College, Wardha, IND.

Department of Obstetrics and Gynecology, Jawaharlal Nehru Medical College, Wardha, IND.

出版信息

Cureus. 2024 Aug 2;16(8):e66018. doi: 10.7759/cureus.66018. eCollection 2024 Aug.

DOI:10.7759/cureus.66018
PMID:39221410
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11366409/
Abstract

Pulmonary mucormycosis is a rare and lethal fungal infection elicited by fungi of the order Mucorales. The disease predominantly affects immunocompromised hosts, like those with diabetes mellitus, hematologic malignancies, or those undergoing immunosuppressive therapy. We, at this moment, report a case of pulmonary mucormycosis in a 55-year-old gentleman, exemplifying the ferocity of clinical disease, diagnostic dilemmas, and rapidity of progression. A diagnosis of pulmonary mucormycosis was based on diagnostic imaging and flexible bronchoscopy. Despite aggressive antifungal and supportive treatment, the patient's condition deteriorated further, and unfortunately succumbed to cardiorespiratory arrest. This case reinforces the importance of early recognition of pulmonary mucormycosis and aggressive medical management, especially in immunocompromised patients, in salvaging lives with good outcomes and preventing the fulminant progression of the disease process.

摘要

肺毛霉病是一种由毛霉目真菌引起的罕见且致命的真菌感染。该疾病主要影响免疫功能低下的宿主,如糖尿病患者、血液系统恶性肿瘤患者或接受免疫抑制治疗的患者。我们在此报告一例55岁男性的肺毛霉病病例,该病例体现了临床疾病的严重性、诊断困境以及病情进展的快速性。肺毛霉病的诊断基于诊断性影像学检查和可弯曲支气管镜检查。尽管给予了积极的抗真菌和支持治疗,但患者病情仍进一步恶化,不幸最终死于心肺骤停。该病例强化了早期识别肺毛霉病并进行积极药物治疗的重要性,尤其是在免疫功能低下的患者中,这对于挽救生命、取得良好预后以及防止疾病过程的暴发性进展至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a55/11366409/3b024f0abf71/cureus-0016-00000066018-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a55/11366409/a41e7c2512ad/cureus-0016-00000066018-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a55/11366409/16d4be5ca5cb/cureus-0016-00000066018-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a55/11366409/63387f0b75b4/cureus-0016-00000066018-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a55/11366409/47bf8458a4d3/cureus-0016-00000066018-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a55/11366409/d6d0290af1c6/cureus-0016-00000066018-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a55/11366409/3b024f0abf71/cureus-0016-00000066018-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a55/11366409/a41e7c2512ad/cureus-0016-00000066018-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a55/11366409/16d4be5ca5cb/cureus-0016-00000066018-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a55/11366409/63387f0b75b4/cureus-0016-00000066018-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a55/11366409/47bf8458a4d3/cureus-0016-00000066018-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a55/11366409/d6d0290af1c6/cureus-0016-00000066018-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a55/11366409/3b024f0abf71/cureus-0016-00000066018-i06.jpg

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本文引用的文献

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Epidemiology and Diagnosis of Mucormycosis: An Update.毛霉病的流行病学与诊断:最新进展
J Fungi (Basel). 2020 Nov 2;6(4):265. doi: 10.3390/jof6040265.
2
Breakfast can Affect Routine Hematology and Coagulation Laboratory Testing: An Evaluation on Behalf of COLABIOCLI WG-PRE-LATAM.早餐会影响常规血液学和凝血实验室检测:代表COLABIOCLI WG-PRE-LATAM进行的一项评估
TH Open. 2019 Dec 17;3(4):e367-e376. doi: 10.1055/s-0039-3401002. eCollection 2019 Oct.
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Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium.
全球毛霉病诊断和管理指南:欧洲医学真菌学会联合会与真菌感染研究组教育和研究联盟合作开展的一项倡议。
Lancet Infect Dis. 2019 Dec;19(12):e405-e421. doi: 10.1016/S1473-3099(19)30312-3. Epub 2019 Nov 5.
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The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports.毛霉病的流行病学和临床表现:病例报告的系统评价和荟萃分析。
Clin Microbiol Infect. 2019 Jan;25(1):26-34. doi: 10.1016/j.cmi.2018.07.011. Epub 2018 Jul 21.
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Recent Advances in the Pathogenesis of Mucormycoses.近年来毛霉病发病机制的研究进展。
Clin Ther. 2018 Jun;40(6):894-902. doi: 10.1016/j.clinthera.2018.03.009. Epub 2018 Apr 6.
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Future directions in mucormycosis research.未来的毛霉病研究方向。
Clin Infect Dis. 2012 Feb;54 Suppl 1(Suppl 1):S79-85. doi: 10.1093/cid/cir886.
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Epidemiology and clinical manifestations of mucormycosis.毛霉病的流行病学和临床表现。
Clin Infect Dis. 2012 Feb;54 Suppl 1:S23-34. doi: 10.1093/cid/cir866.
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Pathogenesis of mucormycosis.毛霉病的发病机制。
Clin Infect Dis. 2012 Feb;54 Suppl 1(Suppl 1):S16-22. doi: 10.1093/cid/cir865.
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