Unidad de Cuidados Intensivos, Sección de Trasplantes y Cuidados Postoperatorios, Hospital Regional Universitario de Málaga, Malaga, Spain.
Departamento de Medicina y Dermatología, Facultad de Medicina, Universidad de Málaga, Malaga, Spain.
Int J Artif Organs. 2024 Nov;47(11):858-861. doi: 10.1177/03913988241274252. Epub 2024 Sep 2.
Hepatopulmonary syndrome (HPS) poses a significant challenge in liver transplant patients, affecting between 10% and 30% of candidates. Historically, HPS was considered a contraindication for liver transplantation due to its association with high mortality rates. However, recent studies have shown improvements in pulmonary function post-transplant, leading to the inclusion of these patients as candidates. Despite this progress, approximately one-fifth of liver transplant recipients develop severe postoperative hypoxia, further complicating their clinical course and contributing to increased mortality. The management of post-transplant HPS involves various strategies, including extracorporeal membrane oxygenation (ECMO), although its use remains infrequently reported. Theoretical models suggest that oxygenation typically improves within 10 days post-transplant, while resolution of HPS may take 6-12 months, making ECMO an attractive possibility as a bridge to recovery in this population. We present a case were ECMO was used in this context.
肝肺综合征 (HPS) 给肝移植患者带来了重大挑战,影响了 10% 至 30%的候选者。历史上,由于 HPS 与高死亡率相关,因此被认为是肝移植的禁忌症。然而,最近的研究表明,移植后肺功能有所改善,使得这些患者成为候选者。尽管取得了这一进展,但大约五分之一的肝移植受者术后会出现严重的低氧血症,进一步使他们的临床病程复杂化,并导致死亡率增加。肝移植后 HPS 的治疗包括各种策略,包括体外膜氧合 (ECMO),尽管其使用仍很少有报道。理论模型表明,移植后 10 天内通常会改善氧合,而 HPS 的缓解可能需要 6-12 个月,因此 ECMO 作为这一人群恢复的桥梁是一种有吸引力的可能性。我们介绍了一个在这种情况下使用 ECMO 的病例。